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1458031-48-5

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1458031-48-5 Structure

1458031-48-5 Structure
IdentificationBack Directory
[Name]

RU-SKI 201
[CAS]

1458031-48-5
[Synonyms]

RU-SKI 201
[Molecular Formula]

C20H27N3OS
[MOL File]

1458031-48-5.mol
[Molecular Weight]

357.51
Chemical PropertiesBack Directory
[Boiling point ]

520.7±50.0 °C(Predicted)
[density ]

1.140±0.06 g/cm3(Predicted)
[pka]

8.46±0.30(Predicted)
Hazard InformationBack Directory
[Uses]

RUSKI-201 is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor, with an IC50 of 0.20 μM. RUSKI-201 is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function[1].
[References]

[1] Ursula R Rodgers, et al. Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. DOI:10.1021/acschembio.6b00896
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