| Identification | More | [Name]
Chlorotributyltin | [CAS]
1461-22-9 | [Synonyms]
CHLOROTRIBUTYLSTANNANE
CHLOROTRIBUTYLTIN
CHLOROTRI-N-BUTYLTIN
N-TRI-TERT-BUTYLTIN CHLORIDE
TBTC
tributylchlorostannane
TRIBUTYLCHLOROTIN
TRIBUTYLTIN CHLORIDE
TRIBUTYLTIN(IV) CHLORIDE
TRIBUTYLTIN(IV) CHLORIDE-D27
TRI-N-BUTYLCHLOROTIN
TRI-N-BUTYL-D27-TIN CHLORIDE
TRI-N-BUTYLTIN CHLORIDE
Chloride tri-n-butyltin
chloridtri-n-butylcinicity
chlorotributyl-stannan
Monochlorotributyltin
Stannane, chlorotributyl-
Stannane, tributylchloro-
Tin, tri-n-butyl-, chloride | [EINECS(EC#)]
215-958-7 | [Molecular Formula]
C12H27ClSn | [MDL Number]
MFCD00000521 | [Molecular Weight]
325.51 | [MOL File]
1461-22-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless liquid. Soluble
in the common organic solvents; including
alcohol, heptane, benzene, and toluene; insoluble
in cold water, but hydrolyzes in hot water. | [Melting point ]
-9 °C | [Boiling point ]
171-173 °C25 mm Hg(lit.) | [density ]
1.2 g/mL at 25 °C(lit.)
| [vapor pressure ]
<0.01 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.492(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
0.017g/l | [form ]
liquid | [color ]
colorless | [Specific Gravity]
1.186 | [Water Solubility ]
PRACTICALLY INSOLUBLE | [Sensitive ]
Moisture Sensitive | [BRN ]
3535715 | [Exposure limits]
ACGIH: TWA 0.1 mg/m3; STEL 0.2 mg/m3 (Skin)
NIOSH: IDLH 25 mg/m3; TWA 0.1 mg/m3 | [Stability:]
Hygroscopic | [InChIKey]
GCTFWCDSFPMHHS-UHFFFAOYSA-M | [LogP]
2.21 at 23℃ | [CAS DataBase Reference]
1461-22-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Tri-n-butyltin chloride(1461-22-9) | [EPA Substance Registry System]
1461-22-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
R21:Harmful in contact with skin.
R25:Toxic if swallowed.
R36/38:Irritating to eyes and skin .
R48/23/25:Toxic: danger of serious damage to health by prolonged exposure through inhalation and if swallowed .
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S35:This material and its container must be disposed of in a safe way .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 2788 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
WH6820000
| [F ]
3-9-21 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29310095 | [Hazardous Substances Data]
1461-22-9(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Hazard]
A poison by ingestion and skin contact.
A severe eye irritant. Tributyl tin compounds are
extremely toxic to marine life. | [Chemical Properties]
Colorless liquid. Soluble
in the common organic solvents; including
alcohol, heptane, benzene, and toluene; insoluble
in cold water, but hydrolyzes in hot water. | [Uses]
Tributyltin Chloride is a triorganotin compound with insecticidal acitivity. Tributyltin Chloride is an endocrine disruptor as well as an inhibitor for the V-ATPases (potential targets in the treatmen
t of diseases such as osteoporosis and cancer). | [Uses]
Tri-n-butyltin chloride is used as an endocrine disruptor as well as an inhibitor for the V-ATPases. It is also used as a rodent-repellent for cable coatings. Further, it is used in hot end glass coating. It also employed as a corrosion remover. | [Definition]
ChEBI:Tributyltin chloride is an inorganic molecular entity. | [Preparation]
Tributyltin chloride is prepared by a redistribution reaction by combining stannic chloride and tetrabutyltin:
3 (C4H9)4Sn + SnCl4 → 4 (C4H9)3SnCl. | [Flammability and Explosibility]
Notclassified | [Toxicology]
Tributyltin chloride (TBTCL) is a widely used biocide and heat stabiliser for PVC compositions. TBTCL has been detected in humans and may cause harmful effects on the thyroid, cardiovascular and other organs in humans. It is also an endocrine disruptor with toxic effects on the male reproductive system.TBTCL causes apoptosis and cell cycle arrest. Activation of endoplasmic reticulum stress and inhibition of autophagy are responsible for TBTCL-induced apoptosis and cell cycle arrest. |
| Questions And Answer | Back Directory | [Description]
Tributyltin chloride is also as Chlorotributyltin, is the chloride of tributyltin. It is a biocide that contaminates foods, especially shellfish. It is an endocrine disrupter in several marine species and is neurotoxic and immuno-toxic in mammals. It has been used as a heat stabilizer, agricultural pesticide and component of antifouling paints2. However, it is perhaps the most acutely toxic chemical to aquatic organisms ever deliberately introduced to water. It has been demonstrated to have an adverse effect on shellfish in France and England, and as a consequence the use of tributyltin‐containing antifouling paints has been restricted in these countries. Other countries have banned the use of tributyltin‐containing antifouling paints or are contemplating restrictions3. | [References]
- Cooke, G. M., et al. Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association 42.2(2004):211-220.
- Nakatsu, Yusuke, Y. Kotake, and S. Ohta. "Tributyltin-induced cell death is mediated by calpain in PC12 cells."Neurotoxicology 27.4(2006):587-593.
- Maguire, R. James. "Environmental aspects of tributyltin." Applied Organometallic Chemistry 1.6(1987):475-498.
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