ChemicalBook--->CAS DataBase List--->14897-39-3

14897-39-3

14897-39-3 Structure

14897-39-3 Structure
IdentificationBack Directory
[Name]

Rifamycin Sodium
[CAS]

14897-39-3
[Synonyms]

Rifamycin SV s
RIFAMYCIN SODIUM
Rifamycinsodiumsal
RIFAMYCIN SV-SODIUM
Rifamycin sodium CRS
RIFAMPICIN SV SODIUM
rifamycin sodium salt
Rifamycin Na USP/EP/BP
Rifamycin SV Monosodium
RIFAMYCIN,MONOSODIUMSALT
RIFAMYCIN SV SODIUM SALT
Rifamycin Sodium USP/EP/BP
RifaMycin SV MonosodiuM salt
RifaMycin, sodiuM salt (1:1)
Rifamycin SV sodium, >=900 IU/mg
RIFAMYCIN SV SODIUM SALT HEXAHYDRATE
Rifamycin SV hexahydrate sodium salt
Rifamycin SV Sodium Salt (Rifaximin EP Impurity C Sodium Salt)
5,6,9,17,19,21-Hexahydroxy-23-Methoxy-2,4,12,16,18,20,22-heptaMethyl-
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, monosodium salt
(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione sodium salt
[EINECS(EC#)]

238-965-7
[Molecular Formula]

C37H46NNaO12
[MDL Number]

MFCD00056847
[MOL File]

14897-39-3.mol
[Molecular Weight]

719.75
Chemical PropertiesBack Directory
[Melting point ]

>215°C (dec.)
[storage temp. ]

-20°C Freezer
[solubility ]

ethanol: soluble50mg/mL
[form ]

powder
[color ]

Dark Red
[Water Solubility ]

Soluble in water, alcohol and dimethyl sulfoxide.
[Merck ]

13,8302
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
[RTECS ]

KD1922500
[F ]

8-10-23
Raw materials And Preparation ProductsBack Directory
[Raw materials]

RIFAMYCIN SV
Hazard InformationBack Directory
[Chemical Properties]

Dark Red Solid
[Uses]

Semi-synthetic antibiotic derived from Rifamycin S. Antibacterial. Potency >900 units (dry basis).
[Biological Activity]

Rifamycin SV inhibits selective (E. coliB. subtilis) bacterial DNA-dependent RNA polymerase by binding to the polymerase β-subunita mechanism similar to rifabutin. It acts as a selective cytochrome P450 3A4 inducer. It is active against Gram-positive bacteria and is moderately active against Gram-negative organisms.
[in vivo]

Rifamycin (5 mg/day; s.c.; 3 days a week) sodium is effective in mice infected with M. tuberculosis, significantly reducing the number of viable bacteria in the body[4].
Rifamycin (12.5-25 mg/kg; peritoneal lavage) sodium can improve the survival rate of rats with experimental intraperitoneal infection and significantly reduce the number of intraperitoneal bacteria and adhesion formation[6].
Rifamycin (5-40 mg/kg; esophageal gavage; once a day, 5 days a week; 4 weeks) sodium shortens oral treatment duration in a mouse model of Mycobacterium ulcerans disease[8].
Rifamycin (0.1 mL; intraaural administration; twice daily; 10 days) sodium does not cause hearing loss in adult or weanling rats[9].
Rifamycin (1 mg i.v. bolus followed by 4 mg i.v. infusion; 70 min) sodium interferes with three major steps of Bile acid metabolism in rats with intravenous Sodium cholate (HY-N0324A) infusion, resulting in a significant decrease in bile acid uptake and excretion[10].
Rifamycin (10-160 mg/kg; s.c.; single dose) sodium is approximately 11 times less effective than Metronidazole (HY-B0318) in a mouse Bacteroides fragilis thigh infection model[11].

Animal Model:Male Wistar rats (weight 200-250 g), cecal ligation puncture (CLP)-induced intra-abdominal infection model[6]
Dosage:25 mg/kg, 12.5 mg/kg
Administration:Peritoneal lavage
Result:Improved survival from 50% in the control group to 91.7% in the 25 mg/kg group and 100% in the 12.5 mg/kg group.
Significantly reduced adhesion formation.
Showed a greater reduction in bacterial counts in peritoneal fluid (25 mg/kg).
Spectrum DetailBack Directory
[Spectrum Detail]

Rifamycin Sodium(14897-39-3)1HNMR
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