| Identification | More | [Name]
Tiron | [CAS]
149-45-1 | [Synonyms]
1,2-DIHYDROXY-3,5-BENZENEDISULFONIC ACID DISODIUM SALT MONOHYDRATE
1,2-DIHYDROXYBENZENE-3,5-DISULFONATE DISODIUM SALT
1,2-DIHYDROXYBENZENE-3,5-DISULFONIC ACID, DI NA SALT
1,2-DIHYDROXYBENZENE-3,5-DISULFONIC ACID DISODIUM SALT
1,2-dihydroxybenzene-3,5-disulfonic acid disodium salt hydrate
1,2-DIHYDROXYBENZENE-3,5-DISULFONIC ACID, DISODIUM SALT MONOHYDRATE
1,2-DIHYDROXYBENZENE-3,5-DISULPHONIC ACID DISODIUM SALT
1,2-DIHYDROXYBENZENE-3,5-DISULPHONIC ACID DISODIUM SALT MONOHYDRATE
3,5-PYROCATECHOLDISULFONIC ACID DISODIUM SALT MONOHYDRATE
4,5-DIHYDROXY-1,3-BENZENEDISULFONIC ACID DISODIUM SALT
4,5-DIHYDROXY-1,3-BENZENEDISULFONIC ACID, DISODIUM SALT MONOHYDRATE
4,5-DIHYDROXY-M-BENZENE DISULFONIC ACID DISODIUM SALT
4,5-DIHYDROXY-M-BENZENEDISULFONIC ACID, DISODIUM SALT, MONOHYDRATE
BENZCATECHOL 3,5 DISULFONIC ACID, DISODIUM SALT
CATECHOL-3,5-DISULFONIC ACID DISODIUM SALT MONOHYDRATE
DISODIUM-1,2-DIHYDROXBENZENE-3,5-DISULFONATE MONOHYDRATE
DISODIUM-1,2-DIHYDROXYBENZENE-3,5-DISULFONATE
Disodium 4,5-dihydroxy-1,3-benzenedisulfonate hydrate
DI-SODIUM 4,5-DIHYDROXY-1,3-BENZENEDISULFONATE MONOHYDRATE
DI-SODIUM 4,5-DIHYDROXYBENZENE-1,3-DISULFONATE MONOHYDRATE | [EINECS(EC#)]
205-741-5 | [Molecular Formula]
C6H6Na2O9S2 | [MDL Number]
MFCD00149531 | [Molecular Weight]
332.22 | [MOL File]
149-45-1.mol |
| Chemical Properties | Back Directory | [Appearance]
light tan powder | [Melting point ]
300 °C | [bulk density]
465kg/m3 | [density ]
2.064g/cm3 at 20℃ | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
Store at +15°C to +25°C. | [solubility ]
1350g/l | [form ]
Powder | [color ]
Off-white | [PH]
5.0 (10g/l, H2O, 20℃) | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [λmax]
290-291 nm (buffer pH 2.5) | [Merck ]
14,9465 | [BRN ]
4629740 | [LogP]
0.3 at 25℃ and pH6.5 | [Surface tension]
72.83mN/m at 1g/L and 19.5℃ | [CAS DataBase Reference]
149-45-1(CAS DataBase Reference) | [EPA Substance Registry System]
149-45-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
CZ9263000
| [F ]
3-9 | [HS Code ]
29082000 | [Toxicity]
mouse,LD50,intraperitoneal,6060mg/kg (6060mg/kg),Toxicology. Vol. 62, Pg. 203, 1990. |
| Hazard Information | Back Directory | [Chemical Properties]
light tan powder | [Uses]
In determination of trace metals. | [Uses]
Tiron is a superoxide scavenger used in the study and examination of oxide electronics. Maintains the ability to remove or destroy magnetic moments which may occur on the surface of such materials. | [Definition]
ChEBI: Tiron is an organic molecular entity. | [in vivo]
Tiron (200 mg/kg, oral gavage) ameliorates oxidative stress and inflammation in a murine model of airway remodeling[2].
Tiron (300 mg/kg, i.p., daily for two weeks) alleviated apoptosis of the left ventricular cardiomyocytes in STZ-induced diabetic mice[3].
| Animal Model: | BALB/c mice challenged with Ovalbumin (OVA) aerosol for 8 weeks[2] | | Dosage: | 200 mg/kg | | Administration: | Oral gavage. | | Result: | Inhibited levels of NOx, IL-13 and TGF-β1, and immunoreactivity of NF-κB. |
| Animal Model: | STZ-induced diabetic mice[3] | | Dosage: | 300 mg/kg | | Administration: | i.p., daily for two weeks. | | Result: | Reduced the levels of total oxidized proteins and advanced glycation end products (AGEs)-related proteins.
Inhibited cardiac myocyte apoptosis.
Decreased PKCδ localization on plasma membrane.
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| [Purification Methods]
Recrystallise it from water [Hamaguchi et al. Anal Chim Acta 9 563 1962]. Itisan indicator colour reagent for Fe, Mn, Ti and Mo ions and complexes with Al, Cd, Co, Co, Fe (III), Mn, Pd, UO22+, VO2+ and Zn. [Beilstein 11 IV 630.] |
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