| Identification | More | [Name]
3-Boc-aminomethylpyrrolidine | [CAS]
149366-79-0 | [Synonyms]
3-(BOC-AMINOMETHYL)PYRROLIDINE
(3-PYRROLIDINYLMETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
PYRROLIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
3-N-BOC-AMINOMETHYL PYRROLIDINE
3-(tert-Butoxycarbonylaminomethyl)pyrrolidine
3-BOCAMINOMETHYLPYRROLIDINE 98% | [Molecular Formula]
C10H20N2O2 | [MDL Number]
MFCD04973997 | [Molecular Weight]
200.28 | [MOL File]
149366-79-0.mol |
| Chemical Properties | Back Directory | [Boiling point ]
303.9±15.0 °C(Predicted) | [density ]
0.997±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [form ]
gel/ oil | [pka]
12.71±0.46(Predicted) | [color ]
Yellow | [InChI]
InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-7-8-4-5-11-6-8/h8,11H,4-7H2,1-3H3,(H,12,13) | [InChIKey]
WIEJVMZWPIUWHO-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)NCC1CCNC1 | [CAS DataBase Reference]
149366-79-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 3-Boc-aminomethylpyrrolidine from the compound (CAS:172477-98-4) is as follows:
Example 10: Preparation of N-methyl-6-{[2-({3-[(methylamino)methyl]pyrrolidin-1-yl}carbonyl)thieno[3,2-b]pyridin-7-yl]oxy}-1-naphthalenecarboxamide
A. Preparation of Intermediate 10a.
To a solution of tert-butyl (1-benzylpyrrolidin-3-yl)methylcarbamate (3.0 g, 10.33 mmol) in EtOAc (100 mL) was added Pd(OH)2/C (0.3 g). The mixture was stirred at room temperature under H2 atmosphere for 3 h. After completion of the reaction, it was filtered through diatomaceous earth. The filtrate was concentrated to give a colorless oily product (1.87 g, 90% yield), which could be used in the next reaction without further purification. | [References]
[1] Patent: WO2005/21553, 2005, A1. Location in patent: Page/Page column 54-55 |
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