| Identification | Back Directory | [Name]
5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone | [CAS]
150045-18-4 | [Synonyms]
MS-444
BE-34776
5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone
Naphtho[2,3-c]furan-4(9H)-one, 5,8-dihydroxy-3-methyl- | [Molecular Formula]
C13H10O4 | [MDL Number]
MFCD00923100 | [MOL File]
150045-18-4.mol | [Molecular Weight]
230.22 |
| Chemical Properties | Back Directory | [Boiling point ]
448.7±45.0 °C(Predicted) | [density ]
1.452±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.14±0.20(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
MS-444 inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 μM. | [in vivo]
To test the effects of MS-444 on CRC cell growth in vivo, mice bearing HCT116 cell xenografts receive IP injections of MS-444 (25 mg/kg bw) or vehicle every 48 hr. Over the experiment course, mice do not display any adverse effects and maintained similar weights. Anti-tumor effects of MS-444 are observed with approximately 1.7-fold reduction in tumor size. Mice treated with MS-444 show a marked 2- to 3-fold decrease in microvessel density (MVD), indicating the anti-angiogenic potential of MS-444[2]. | [References]
[1] Satoshi Nakanishi. et al. MS-444, a new inhibitor of myosin light chain kinase from Micromonosporasp.KY7123. The Journal Of Antibiotics. 1995,48(9):948-951. DOI:10.7164/antibiotics.48.948
[2] Fernando F. Blanco.et al, Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. Oncotarget. 2016 Nov 8; 7(45): 74043-74058. DOI:10.18632/oncotarget.12189 |
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