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Cgs 25155 is an orally active NEP 24.11 inhibitor. | [Uses]
CGS25155 is an orally active neutral endopeptidase 24.11 (NEP 24.11) inhibitor with an IC50 of 3 nM. CGS25155 can slow down the degradation of the cardiac hormone atrial natriuretic peptide (ANP) and exhibits antihypertensive activity in the DOCA-salt induced rat hypertension model. CGS25155 can be used in cardiovascular disease research[1]. | [References]
[1] MacPherson LJ, et al. Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor. J Med Chem. 1993 Nov 26;36(24):3821-8. DOI:10.1021/jm00076a009 |
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CHEMICAL LAND21
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www.chemicalland21.com |
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