| Identification | More | [Name]
ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE | [CAS]
15028-41-8 | [Synonyms]
2,2-DIMETHYLGLYCINE METHYL ESTER HYDROCHLORIDE
2-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE
2-METHYLALANINE METHYL ESTER HYDROCHLORIDE
ALPHA-AMINO-2-METHYLBUTYRIC ACID METHYL ESTER HYDROCHLORIDE
ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE
H-AIB-OME HCL
H-ALA(ME)-OME HCL
H-ALPHA-ME-ALA-OME HCL
A-aminoisobutyric acid methyl ester*hydrochloride
methyl α-aminoisobutyrate hydrochloride
α-aminoisobutyric acid methyl ester hydrochloride
METHYL ALPHA-AMINOISOBUTYRATE HYDROCHLORIDE
2-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE 98%
2-Aminoisobutyric acid methyl ester hydrochloride, 2-Methylalanine methyl ester hydrochloride, alpha-Amino-2-methylbutyric acid methyl ester hydrochloride, 2,2-Dimethylglycine methylester hydrochloride | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C5H12ClNO2 | [MDL Number]
MFCD00214247 | [Molecular Weight]
153.61 | [MOL File]
15028-41-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
185°C | [storage temp. ]
−20°C
| [solubility ]
DMSO (Sparingly), Methanol (Slightly), Water (Slightly) | [form ]
Crystalline Powder | [color ]
White | [Water Solubility ]
Slightly soluble in water. | [InChI]
InChI=1S/C5H11NO2.ClH/c1-5(2,6)4(7)8-3;/h6H2,1-3H3;1H | [InChIKey]
NVWZNEDLYYLQJC-UHFFFAOYSA-N | [SMILES]
C(N)(C)(C)C(=O)OC.Cl | [CAS DataBase Reference]
15028-41-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
Methyl α-aminoisobutyrate is used as a specific substrate of amino acid transport system and in studies on amino acid transport systems. | [Synthesis]
1. 2-Amino-2-methylpropionic acid (10 g, 96.9 mmol) and methanol (330 ml) were added to a reaction vial.
2. The reaction vial was placed in an ice bath and thionyl chloride (17.68 ml, 242.25 mmol) was slowly added dropwise.
3. After the dropwise addition was completed, the ice bath was removed and the reaction mixture was stirred at room temperature for 3 hours.
4. After completion of the reaction, the solvent was removed by vacuum distillation.
5. The residue was dried in an oven at 60 °C to give methyl 2-amino-2-methylpropionate hydrochloride as a white solid (14.59 g, 94.9 mmol, 98% yield). 6. The product was analyzed by 1H NMR.
6. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.75 (br, 3H), 3.75 (s, 3H), 1.45 (s, 6H). | [References]
[1] Organic Letters, 2012, vol. 14, # 18, p. 4798 - 4801
[2] European Journal of Organic Chemistry, 2004, # 20, p. 4167 - 4176
[3] Patent: WO2013/19091, 2013, A2. Location in patent: Paragraph 936-938
[4] Patent: US2014/206875, 2014, A1. Location in patent: Paragraph 0513-0514; 0568-0569; 0599-0600; 0658-0660
[5] Tetrahedron, 1982, vol. 38, # 14, p. 2165 - 2182 |
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