| Identification | Back Directory | [Name]
MC3343 | [CAS]
1535187-91-7 | [Synonyms]
MC3343
MC-3343;MC 3343
Benzamide, N-[3-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-3-(4-quinolinylamino)- | [Molecular Formula]
C27H23N7O | [MOL File]
1535187-91-7.mol | [Molecular Weight]
461.52 |
| Hazard Information | Back Directory | [Uses]
MC3343, a DNMT inhibitor (EC50 of 5.7 μM) and a strong DNA binder, affects tumor proliferation by blocking OS cells in G1 or G2/M phases and induces osteoblastic differentiation through the specific re-expression of genes regulating this physiological process[1]. | [References]
[1] Maria Cristina Manara, et al. A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy. Mol Cancer Ther. 2018 Sep;17(9):1881-1892. DOI:10.1158/1535-7163.MCT-17-0818 |
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
| Company Name: |
TargetMol
|
| Tel: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|