1539296-45-1

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1539296-45-1 Structure

Identification	Back Directory
[Name] 1-Methyl-3-(4-methyl-3-pyridinyl)-6-(2-pyridinylmethoxy)-1H-pyrazolo[3,4-b]pyrazine
[CAS] 1539296-45-1
[Synonyms] PF-06297470 PF-06297470 >=98% (HPLC) 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazine 1-Methyl-3-(4-methyl-3-pyridinyl)-6-(2-pyridinylmethoxy)-1H-pyrazolo[3,4-b]pyrazine 1H-Pyrazolo[3,4-b]pyrazine, 1-methyl-3-(4-methyl-3-pyridinyl)-6-(2-pyridinylmethoxy)-
[Molecular Formula] C18H16N6O
[MDL Number] MFCD28100803
[MOL File] 1539296-45-1.mol
[Molecular Weight] 332.36

Chemical Properties	Back Directory
[Boiling point ] 526.8±45.0 °C(Predicted)
[density ] 1.34±0.1 g/cm3(Predicted)
[storage temp. ] 2-8°C
[solubility ] DMSO: soluble5mg/mL, clear (warmed)
[form ] powder
[pka] 3.12±0.12(Predicted)
[color ] white to beige
[InChI] 1S/C18H16N6O/c1-12-6-8-19-9-14(12)16-17-18(24(2)23-16)22-15(10-21-17)25-11-13-5-3-4-7-20-13/h3-10H,11H2,1-2H3
[InChIKey] RDLSKDOSNKLEAQ-UHFFFAOYSA-N
[SMILES] CN(N=C1C2=C(C)C=CN=C2)C3=C1N=CC(OCC4=NC=CC=C4)=N3

Safety Data	Back Directory
[Hazard Codes ] Xn
[Risk Statements ] 22
[WGK Germany ] 3
[Storage Class] 11 - Combustible Solids
[Hazard Classifications] Acute Tox. 4 Oral

Hazard Information	Back Directory
[Uses] PF470 (PF-06297470) is a negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with significant efficacy in Parkinson's disease models, but clinical development was halted due to potential issues found in toxicology studies.
[Biological Activity] PF-06297470 is a potent negative allosteric modulator of the Metabotropic Glutamate Receptor 5 (mGluR5). PF-06297470 binds to mGluR5 with a Ki of 0.9 nM. The compound PF-06297470 displays slight antagonism of mGluR1 (IC50 = 30.5 mM)with no agonist or antagonist activities against any other mGlu receptor subtype at concentrations up to 50 mM. PF-06297470 reduces dyskinesia in a rodent (MPTP)-rendered Parkinsonian model of L-DOPA-induced dyskinesia (PD-LID).
[References] [1] Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator

1539296-45-1 suppliers list

Company Name:	Beijing Biocreative Technology Co., Ltd.
Tel:	15522676233
Website:	www.bestbaiao.com/

Company Name:	Biosynth Biological Technology (Suzhou) Co Ltd
Tel:	51288865780
Website:	www.biosynth.com

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