| Identification | More | [Name]
2,8-Quinolinediol | [CAS]
15450-76-7 | [Synonyms]
2,8-DIHYDROQUINOLINE
2,8-DIHYDROXYQUINOLINE
2,8-QUINOLINEDIOL
8-Hydroxycabostyril
8-HYDROXYCARBOSTYRIL
QUINOLINE-2,8-DIOL
2,8-DIHYDROXY-CHINOLIN
2,8-Dihydroxyquinoleine
2,8-QUINOLINEDIOL,98+%
8-Hydroxy-2(1H)-quinolinone | [EINECS(EC#)]
604-962-8 | [Molecular Formula]
C9H7NO2 | [MDL Number]
MFCD00216696 | [Molecular Weight]
161.16 | [MOL File]
15450-76-7.mol |
| Questions And Answer | Back Directory | [Synthesis]
solution of quinoline-8-ol-1-oxide (20 g, 124 mmol) in acetic anhydride (200 mL) was stirred at 90°C for 5 hours. The reaction mixture was then poured into a water/ice mixture (1.5 L) and neutralized by adding conc. aq. The precipitate formed was collected by filtration and washed with water. The crude product was suspended in propanol and purified by adding petroleum ether to give 2-oxo-1,2-dihydroquinoline-8-acetate. 2-oxo-1,2-dihydroquinoline-8-acetate was heated in a concentrated solution. aq. Soaked in hydrochloric acid (200 mL) at 90°C for 4 hours. The reaction mixture was poured into ice water (400 mL), and the precipitate formed was collected by filtration and washed with water. Recrystallization from propane-2-ol/petroleum ether gave the target compound 2,8-quinolinediol (14.1 g, 70%).
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| Chemical Properties | Back Directory | [Melting point ]
~290 °C (dec.) | [Boiling point ]
403.2±45.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
8.85±0.20(Predicted) | [color ]
Dark Reddish Brown | [λmax]
335nm(EtOH)(lit.) | [BRN ]
472906 | [InChI]
InChI=1S/C9H7NO2/c11-7-3-1-2-6-4-5-8(12)10-9(6)7/h1-5,11H,(H,10,12) | [InChIKey]
ZXZKYYHTWHJHFT-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC=C2O)C=CC1=O | [CAS DataBase Reference]
15450-76-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
2933499090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Brown Powder | [Uses]
2,8-Quinolinediol is a substituted quinolinone derivative used in the preparation of pharmaceutical compounds.
| [Definition]
ChEBI: Quinoline-2,8-diol is a dihydroxyquinoline. It is a tautomer of an 8-hydroxyquinolin-2(1H)-one. | [General Description]
2,8-Quinolinediol is a quinolone derivative. It has been reported as metabolite of 8-hydroxyquinoline-N-oxide in rabbits. Synthesis of 2,8-quinolinediol has been reported. It is reported as one of the six possible forms of 8-hydroxycarbostyril. It has been detected as new UV-absorbing compound (UAC) in cow milk and its structure was elucidated using HRMS and by 1H, 13C and 1H ×13C NMR.It is also known as 8-hydroxycarbostyril or 8-hydroxyquinolin-2(1H)-one. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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