| Identification | More | [Name]
4-Hydroxyquinoline | [CAS]
611-36-9 | [Synonyms]
4(1H)-QUINOLINONE
4-HYDROXY-1-AZANAPHTHALENE
4-HYDROXYQUINOLINE
4-QUINOLINOL
AKOS 222-32
HYDROXYQUINOLINE,4-
KYNURINE
QUINOLIN-4(1H)-ONE
QUINOLIN-4-OL
4-hydroxy-quinolin
4-Hydroxyquinoline98%
1H-Quinolin-4-one
Quinoline, 4-hydroxy- | [EINECS(EC#)]
210-268-2 | [Molecular Formula]
C9H7NO | [MDL Number]
MFCD00006777 | [Molecular Weight]
145.16 | [MOL File]
611-36-9.mol |
| Chemical Properties | Back Directory | [Appearance]
LIGHT BEIGE TO YELLOWISH CRYST. POWDER OR NEEDLES | [Melting point ]
200-202 °C(lit.)
| [Boiling point ]
264.27°C (rough estimate) | [density ]
1.1555 (rough estimate) | [refractive index ]
1.4500 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in methanol. | [form ]
Crystalline Powder or Needles | [pka]
2.23, 11.28(at 20℃) | [color ]
Light beige to yellow | [Water Solubility ]
4.8g/L(15 ºC) | [Detection Methods]
HPLC,NMR | [BRN ]
1524969 | [InChI]
1S/C9H7NO/c11-9-5-6-10-8-4-2-1-3-7(8)9/h1-6H,(H,10,11) | [InChIKey]
PMZDQRJGMBOQBF-UHFFFAOYSA-N | [SMILES]
Oc1ccnc2ccccc12 | [LogP]
2.450 (est) | [CAS DataBase Reference]
611-36-9(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Quinolinol(611-36-9) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
VC4070000
| [HS Code ]
29334900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
4-Hydroxyquinoline is a quinoline alkaloid that has been found in Z. lotus honeys. It is a core component of alkyl-4-hydroxyquinoline quorum sensing molecules such as 2-heptyl-3-hydroxy-4(1H)-quinolone and 2-nonyl-3-hydroxy-4-quinolone. 4-Hydroxyquinoline has been used as a precursor in the synthesis of compounds with antibacterial activity. It has also been used as a fluorescent detection reagent for iron(III) in bovine liver samples.
| [Chemical Properties]
LIGHT BEIGE TO YELLOWISH CRYST. POWDER OR NEEDLES | [Uses]
4-Hydroxyquinolineis a hydroxylated quinoline derivative with antimicrobial activity. 4-Hydroxyquinoline showed growth-inhibitory effects against intestinal bacteria. 4-Hydroxyquinoline act as sacrifi
cial scavengers of the photogenerated oxygen species and has been shown to prevent the photodegradation of riboflavin. | [Definition]
ChEBI: A monohydroxyquinoline carrying a hydroxy group at position 4. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 68, p. 1264, 1946 DOI: 10.1021/ja01211a038 | [General Description]
4-Quinolinol (4-quinolone) is a quinolone compound which forms the core moiety of antibacterials such as norfloxacin, nalidixic acid, ciprofloxacin and cinoxacin. | [Biological Activity]
4-hydroxyquinoline is a hydroxylated quinoline derivative with antimicrobial activity. it shows growth-inhibitory effects against intestinal bacteria. it also can be used as sacrificial scavengers of the photogenerated oxygen species. | [storage]
Store at -20°C | [References]
[1] F. KHALLOUKI. HPLC-ESI-MS and GC-EI-MS Identification and Quantitation of Polyphenolics and Alkaloids in Moroccan Jujube Honeys[J]. Journal of Apicultural Science, 2020, 64 1: 287-299. DOI: 10.2478/jas-2020-0029
[2] STEPHAN HEEB. Quinolones: from antibiotics to autoinducers[J]. FEMS microbiology reviews, 2011, 35 2: 247-274. DOI: 10.1111/j.1574-6976.2010.00247.x
[3] MARIE-GRATIA KAYIRERE . Synthesis and antibacterial activity of new 4-alkoxy, 4-aminoalkyl and 4-alkylthioquinoline derivatives[J]. European Journal of Medicinal Chemistry, 1998, 33 1: Pages 55-63. DOI: 10.1016/s0223-5234(99)80076-2
[4] GEORGE C. RAGOS Prodromos B I Mavroudis A Demertzis. A high-sensitive spectrofluorimetric method for the determination of micromolar concentrations of iron(III) in bovine liver with 4-hydroxyquinoline[J]. Farmaco (Societa chimica italiana?: 1989), 1998, 53 8: Pages 611-616. DOI: 10.1016/s0014-827x(98)00070-6 |
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Energy Chemical
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