| Identification | Back Directory | [Name]
2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether | [CAS]
154675-18-0 | [Synonyms]
Hhbpdde
[1,1'-Biphenyl]-2,2',3,3',4,4'-hexol, 6,6'-bis(methoxymethyl)- | [Molecular Formula]
C16H18O8 | [MDL Number]
MFCD00925616 | [MOL File]
154675-18-0.mol | [Molecular Weight]
338.31 |
| Chemical Properties | Back Directory | [Melting point ]
165-168℃ | [storage temp. ]
-20°C | [solubility ]
ethanol: 1mg/mL
warm water: 1mg/mL
DMSO: 5mg/mL | [form ]
Orange solid. | [color ]
Brown to khaki | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2]. | [Definition]
ChEBI: 5-(methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol is a tannin. | [Biological Activity]
Cell permeable: yes''Primary Target
PKCα''Product does not compete with ATP.''Reversible: no''Target IC50: 43 μM against PKCα | [IC 50]
PKCα: 43 μM (IC50); PKCγ: 50 μM (IC50) | [References]
[1] A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15. DOI:10.1016/s0006-2952(00)00398-1
[2] Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195-200. DOI:10.1021/jm00027a025 |
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