ChemicalBook--->CAS DataBase List--->137592-47-3

137592-47-3

137592-47-3 Structure

137592-47-3 Structure
IdentificationBack Directory
[Name]

BISINDOLYLMALEIMIDE VII
[CAS]

137592-47-3
[Synonyms]

BISINDOLYLMALEIMIDE VII
[Molecular Formula]

C27H27N5O2
[MDL Number]

MFCD01076634
[MOL File]

137592-47-3.mol
[Molecular Weight]

453.54
Chemical PropertiesBack Directory
[Boiling point ]

761.6±60.0 °C(Predicted)
[density ]

1.39±0.1 g/cm3(Predicted)
[storage temp. ]

−20°C
[solubility ]

DMSO: soluble
[form ]

solid
[pka]

8.18±0.60(Predicted)
[InChIKey]

VKLVUAHQOFDKLR-UHFFFAOYSA-N
[SMILES]

O=C1NC(=O)C(c2cn(CCCN3CCNCC3)c4ccccc24)=C1c5c[nH]c6ccccc56
Safety DataBack Directory
[WGK Germany ]

3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

Bisindolylmaleimide VII is a potent inhibitor of calmodulin with high affinity for calmodulin (Kd=186.2 nM). Bisindolylmaleimide VII is used to study the role of calmodulin in cancer, neurodegenerative diseases, and muscle dysfunction[1].
[Biological Activity]

Selective inhibitor of protein kinase C.
[References]

[1] Sosa-Peinado, et al. Bisindolylmaleimides new ligands of CaM Protein. Molecules 27.21 (2022): 7161. DOI:10.3390/molecules27217161
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