| Identification | Back Directory | [Name]
CCK-B Receptor Antagonist 2 | [CAS]
155412-88-7 | [Synonyms]
CCK-B Receptor Antagonist 2 | [Molecular Formula]
C27H28N6O3 | [MDL Number]
MFCD32690098 | [MOL File]
155412-88-7.mol | [Molecular Weight]
484.55 |
| Chemical Properties | Back Directory | [Boiling point ]
725.1±60.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (515.94 mM) | [form ]
Solid | [pka]
11.35±0.40(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM[1]. | [in vivo]
CCK-B Receptor Antagonist 2 (0.1 μmol/kg; intravenous injection) has an inhibition effect on pentagastrin-induced gastric acid secretion in anethsetized rats with an ED50 of 8.3 nmol/kg[1]. | [IC 50]
CCKBR | [References]
[1] Semple G, et al. (3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.J Med Chem. 1997 Jan 31;40(3):331-41. DOI:10.1021/jm960669+ |
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