| Identification | More | [Name]
Licofelone | [CAS]
156897-06-2 | [Synonyms]
ML 3000
2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid
2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
Licofelone, ML-3000
[2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
Licofelone
6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid | [EINECS(EC#)]
694-581-3 | [Molecular Formula]
C23H22ClNO2 | [MDL Number]
MFCD00929900 | [Molecular Weight]
379.88 | [MOL File]
156897-06-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellowish Solid | [Melting point ]
162-163°C | [Boiling point ]
539.7±50.0 °C(Predicted) | [density ]
1.23 | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform, Methanol | [form ]
Solid | [pka]
4.47±0.10(Predicted) | [color ]
Off-White to Light Yellow | [Usage]
Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory | [CAS DataBase Reference]
156897-06-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1β (IL-1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E2, leukotriene B4, and lipoxins and prevents lipopolysaccharide-stimulated IL-1β expression.1 The IC50 values for inhibition of human thrombocyte COX and human 5-LO are 0.16 μM and 0.23 μM, respectively.2 Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.3 | [Chemical Properties]
Yellowish Solid | [Uses]
Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory | [Uses]
Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory. | [in vitro]
the 5-lox and cox inhibitory effect of licofelone was firstly identified via bovine thromobocyte intact cell assay and intact bovine pmn leukocytes. licofelone was also reported to inhibit pge2 in a dose-dependent manner in human whole blood assay. moreover, licofelone was found to suppress in vitro generation of reactive oxygen species and to reduce release of elastase from pmn leukocytes. all above findings revealed that licofelone had an inhibitory effect on cox-1/-2 and 5-lox. [1] | [in vivo]
the pharmacodynamic properties of licofelone were evaluated in various animal models and compared with those of commonly used nsaids. based on studies from a rat model of incisional pain, orally administration of licofelone had a longer duration of action and was more effective than indomethacin and zileuton. [1] | [IC 50]
inhibitor of cox-1, cox-2 and 5-lox with ic50 values of 0.16 m, 0.37 m and 0.23 m respectively in human. | [References]
[1]kulkarni sk and singh vp. licofelone-a novel analgesic and anti-inflammatory agent. curr top med chem. 2007; 7(3): 251-63. |
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