| Chemical Properties | Back Directory | [Melting point ]
190-191 °C | [density ]
1.510±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
8.667±0.70(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Casein kinase 1δ-IN-6 is a potent and selective protein kinase CK-1δ inhibitor with an IC50 of 23 nM. Casein kinase 1δ-IN-6 shows neuroprotective and anti-inflammatory properties both in vitro and in vivo. Casein kinase 1δ-IN-6 is a promising drug candidate and can be used for neurodegenerative diseases research. | [References]
[1] José A Morales-Garcia, et al. Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson's Disease. ACS Omega. 2017 Aug 31;2(8):5215-5220. DOI:10.1021/acsomega.7b00869 |
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