| Identification | Back Directory | [Name]
2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate | [CAS]
160969-03-9 | [Synonyms]
Silodosin Intermediate 1
2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate
2-[2-(2,2,2-trifluoroethoxy)phenoxy]-ethanol-1-Methanesulfonate
Ethanol,2-[2-(2,2,2-trifluoroethoxy)phenoxy]-, 1-Methanesulfonate | [EINECS(EC#)]
801-482-2 | [Molecular Formula]
C11H13F3O5S | [MDL Number]
MFCD16038209 | [MOL File]
160969-03-9.mol | [Molecular Weight]
314.28 |
| Chemical Properties | Back Directory | [Melting point ]
52.0 to 56.0 °C | [Boiling point ]
396.4±42.0 °C(Predicted) | [density ]
1.362 | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1S/C11H13F3O5S/c1-20(15,16)19-7-6-17-9-4-2-3-5-10(9)18-8-11(12,13)14/h2-5H,6-8H2,1H3 | [InChIKey]
HOJMCBMXHWZNKX-UHFFFAOYSA-N | [SMILES]
C(OS(C)(=O)=O)COC1=CC=CC=C1OCC(F)(F)F |
| Hazard Information | Back Directory | [Uses]
2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy. | [Synthesis]
Anhydrous AlCl3 ( 165 g, 1 .24 mol) and 200 mL of anhydrous dichloromethane were mixed, cooled to -5 ℃ under nitrogen protection, methane sulfonyl chloride was added dropwise with stirring, and then stirred at room temperature for 30 min after the dropwis |
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