| Identification | More | [Name]
(R)-(+)-1-(1-Naphthyl)ethylamine | [CAS]
3886-70-2 | [Synonyms]
(1R)-(1-NAPHTHALEN-1-YL)ETHANAMINE
D-A-(1-NAPHTHYL)ETHYLAMINE
(R)-(+)-1-(1-NAPHTHYL)ETHYLAMINE
(R)-1-(1-NAPHTHYL)ETHYLAMINE
(R) 1-(1-NAPTHYL)ETHYLAMINE
(R)-1-(NAPHTHALEN-1-YL)ETHANAMINE
(R)-(+)-1-(NAPHTHYL)ETHYLAMINE
(R)-(+)-A-(1-NAPHTHYL)ETHYLAMINE
(R)-(+)-ALPHA-(1-AMINOETHYL)NAPHTHALENE
(R)-(+)-ALPHA-(1-NAPHTHYL)ETHYLAMINE
(theta)-1-naphthalenemethanamin
(R)-(+)-α-Methyl-1-naphthalenemethylamine
R-PLUS-A-1-NAPHTHYL-ETHYLAMINE
(R)-(+)-1-(1-NAPHTHYL)ETHYLAMINE 99%
(R)-(+)-1-(Napthyl)ethylamine, 99%
(R)-(+)-alpha-(1-Naphthyl)ethylamine, 99+%
1-Naphthalenemethanamine, .alpha.-methyl-, (.alpha.R)-
(R)-(+)-1-(Naphth-1-yl)ethylamine
R-(+)-NAPHTHYLETHYLAMINE
(R)-(+)--(1-NAPHTHYL) ETHYLAMINE 98% | [EINECS(EC#)]
223-425-5 | [Molecular Formula]
C12H13N | [MDL Number]
MFCD00064114 | [Molecular Weight]
171.24 | [MOL File]
3886-70-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Melting point ]
135-136 °C | [alpha ]
60 º (c=2, CH3OH) | [Boiling point ]
153 °C11 mm Hg(lit.)
| [density ]
1.067 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.623(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
9.26±0.40(Predicted) | [color ]
brown
| [Specific Gravity]
1.07 | [Stability:]
Stable. Air-sensitive. Incompatible with acids, oxidizing agents, acid anhydrides, chloroformates, acid chlorides. | [Optical Rotation]
[α]20/D +55°, c = 2 in ethanol | [Water Solubility ]
Soluble in water (<10/l). | [Sensitive ]
Air Sensitive | [BRN ]
2208025 | [InChI]
1S/C12H13N/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11/h2-9H,13H2,1H3/t9-/m1/s1 | [InChIKey]
RTCUCQWIICFPOD-SECBINFHSA-N | [SMILES]
C[C@@H](N)c1cccc2ccccc12 | [CAS DataBase Reference]
3886-70-2(CAS DataBase Reference) | [EPA Substance Registry System]
3886-70-2(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
2735 | [WGK Germany ]
3
| [RTECS ]
QJ6963000 | [F ]
10-34 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29214500 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
(R)-(+)-1-(1-Naphthyl)ethylamine is a reagent used in the formation of isolated acids via salt formation. It is also a raw material for the synthesis of (R)-1-(1-Naphthyl)ethyl isocyanate. In materials research, the use of Reflectance Absorption Infrared Spectroscopy (RAIRS) can be used to study the structure, bonding and orientation of R-1- nea and (S)-(-)-1-(2-naphthyl)ethylamine (S-2- nea) on Pd(1 1 1). | [Chemical Properties]
Colorless to light yellow liqui | [Uses]
(R)-(+)-1-(1-Naphthyl)ethylamine(3886-70-2) is used in chiral synthesis in organic reactions including the synthesis of β-amino acids and the enantioselective of ketones to nitroolefins.
| [Application]
Absolute configuration of primary amines determined using chiral (2-nitrophenyl)proline amides and 1H NMR. | [Preparation]
There are three main methods for preparing (R)-(+)-1-(1-Naphthyl)ethylamine:
(1) Enzymatic separation method;
(2) Chemical separation method, with the following separation agents used: chiral aspartic acid, chiral α-hydroxy naphthoic acid, protective chiral glycerol derivatives, and chiral tartaric acid;
(3) Dissymmetric synthesis, etc.
Using dissymmetric synthesis as an example, obtain Chiral Amine to prochiral ketone oxime through asymmetric catalytic hydrogenation reduction, method adopts ammonium formiate to reduce by 1-(1-naphthyl) acetophenone oxime, at chlorine { [(1R, 2R)-(-)-2-ammonia-1,2-Diphenethyl] (4-tolylsulfonyl) ammonia (p-isopropyl toluene) ruthenium (II)) catalyzer exist under, adopt polar solvent as dimethyl formamide, methyl alcohol, ethanol, n-propyl alcohol, Virahol, butanols, the one in the trimethyl carbinol.Catalytic asymmetric reduction single step reaction preparation (R)-(+)-1-(1-naphthyl) ethamine is carried out to 1-(1-naphthyl) acetophenone oxime. | [General Description]
(R)-(+)-1-(1-Naphthyl)ethylamine(3886-70-2) is a chiral derivatization reagent useful for all gas chromatography (GC) applications in the chiral field. It is specially selected to meet the requirements for derivatization reagents for enantiomeric excess determinations.
| [Solubility in organics]
(R)-(+)-1-(1-Naphthyl)ethylamine is soluble in chloroform and ethanol. Insoluble in water. | [Purification Methods]
Purify the amine by distillation in a good vacuum. [Mori et al. Tetrahedron 37 1343 1981, cf Wilson in Topics Stereochem (Allinger and Eliel eds) v o l 6 135 1971, Fredga et al. Acta Chem Scand 11 1609 1957.] The hydrochlorides crystallise from H2O [] D 18 ±3.9o (c 3, H2O), and the sulfates recrystallise from H2O as tetrahydrates m 230-232o. The RS-amine has b 153o/11mm, 156o/15mm, 183.5o/41mm [Blicke & Maxwell J Am Chem Soc 6 1 1780 1939]. [Beilstein 12 III 3111.] |
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