| Identification | Back Directory | [Name]
TCO-Amine Hydrochloride | [CAS]
1609736-43-7 | [Synonyms]
TCO-amine
TCO-Amine Hydrochloride
Cyclooct-4-en-1-yl (3-aminopropyl)carbamate
Carbamic acid, N-(3-aminopropyl)-, 4-cycloocten-1-yl ester | [Molecular Formula]
C12H22N2O2 | [MOL File]
1609736-43-7.mol | [Molecular Weight]
226.32 |
| Hazard Information | Back Directory | [Description]
TCO-Amine is a click chemistry building block containing a TCO moiety and a free amine. Amine is very reactive with active NHS ester or conjugate with carboxylic acid in the presence of of activators suh as EDC. The low mass weight will add minimal spacer to modified molecules. TCO moiety is very reactive with tetrazine ( 3rd generation click chemistry). | [Uses]
TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl-Chain | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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