| Identification | Back Directory | [Name]
(2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-(2-METHOXYETHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE | [CAS]
163759-97-5 | [Synonyms]
2'-O-MOE-U Phosphoramidite
2'-O-MOE-rU Phosphoramidite
2'-O-MOE-U-CE Phosphoramidite
2'-O-MOE-U-3'-phosphoramidite
DMT-2'-O-MOE-U-CE-Phosphoramidite
5'-O-DMT-2'-(2-methoxyethyl)uridine 3'-CE phosphoramidite
5'-O-DMT-2'-O-(2-methoxyethyl)uridine 3'-CE phosphoramidite
5'-O-DMTr-2'-O-(2-methoxyethyl)-uridine-3'-CED-phosphoramidite
5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-uridine-3'-cyanoethyl Phosphoramidite
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)uridine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
(2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-(2-METHOXYETHOXY)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE | [Molecular Formula]
C42H53N4O10P | [MDL Number]
MFCD11505866 | [MOL File]
163759-97-5.mol | [Molecular Weight]
804.86 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, protect from light | [form ]
Solid | [pka]
9.39±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
ZLOKLUONKGURQI-LWTSSKLSNA-N | [SMILES]
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,36,42,r| |
| Hazard Information | Back Directory | [Description]
2'-O-MOE-U-3'-phosphoramidite (DMT-2'-O-MOE-rU Phosphoramidite) is a 2'-O-MOE-protected nucleoside phosphoramidite that can be inserted into oligonucleotide phosphoramidites for antisense RNA. The 2'-MOE backbone enhances stability, resists nuclease, and exhibits low toxicity for improved genetic manipulation. | [Chemical Properties]
White to Light yellow powder to crystal | [Uses]
2'-O-MOE-U is a phosphoramidite, can be used for oligonucleotide synthesis[1]. | [storage]
4°C, protect from light | [References]
[1] Lyu F, et al. A 2'-modified uridine analog, 2'-O-(methylthiomethoxy)methyl uridine, for siRNA applications. Bioorg Med Chem Lett. 2022 Oct 15;74:128939. DOI:10.1016/j.bmcl.2022.128939 |
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