| Identification | Back Directory | [Name]
PVM/MA | [CAS]
1644545-52-7 | [Synonyms]
E7386
AG881
AG081
HS-01
AG-881
E-7386
PVM/MA
s-22611
FF10101
CS-2621
IMB-XH1
FF-10101
15-HPETE
PCB138/160
PF06291874
Vorasidenib
(+)-Quassin
FM381 FM-381
AG 881; AG-881
Vorasidenib (AG881)
FLEABUSTERSRXPOWDER
(E)-Ethyl Docos-2-Enoate
benzyl ester of L-carnitine
Amino Carboxyl Magnetic Beads
S-N-NITROSO-2-METHYLPIPERIDINE
15-HYDROPEROXYEICOSATETRAENOICACID
3-bromo-5-bromoacetyl salicylamide
CALCIUM(C10-C16)ALKYLBENZENESULPHONATE
2-chloro-N1,N4-bis(4-cyanophenyl)terephthalamide
4-(2-acetyl-5-chlorophenyl)-5-methoxypyridin-2(1H)-one
2,2'-(propane-2,2- diylbis(sulfanediyl))bis(ethan-1-ol)
(5Z,8Z,11Z,14Z)-15-Hydroperoxy-5,8,11,14-icosatetraenoic acid
(5Z,8Z,11Z,14Z)-15-Hydroperoxyicosa-5,8,11,14-tetraenoic acid
N,N-dimethyl-N-(oxiran-2-ylmethyl)octadecan-1-aminium chloride
2-[1-(2-Hydroxy-ethylsulfanyl)-1-methyl-ethylsulfanyl]-ethanol
Trichloroethyl 2-(Bromomethyl)-2-hydroxyhehahydrofuro(3,2-b)pyridine-4(2H)-carboxylate
6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine
1,3,5-Triazine-2,4-diamine, 6-(6-chloro-2-pyridinyl)-N2,N4-bis[(1R)-2,2,2-trifluoro-1-methylethyl]-
2-[3-(2H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-1,5-benzodiazepin-1-yl]-N-(4-methoxyphenyl)-N-propan-2-ylacetamide
(R)-1-(3-(3-amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylic acid?
4-N-(2,4-dimethoxyphenyl)-6-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-4,6-diamine, N4-(2,4-dimethoxyphenyl)-N6-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-4,6-diamine | [Molecular Formula]
C14H13ClF6N6 | [MDL Number]
MFCD31630835 | [MOL File]
1644545-52-7.mol | [Molecular Weight]
414.74 |
| Chemical Properties | Back Directory | [Boiling point ]
467.5±55.0 °C(Predicted) | [density ]
1.491±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml | [form ]
A crystalline solid | [pka]
1.49±0.41(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
PF-06291874 is a novel and potent glucagon receptor antagonist for the potential treatment of diabetes mellitus. PF-06291874, has a lower molcular weight and lipophilicity than historical glucagon receptor antagonists, resulting in excellent selectivity in broad-panel screening, lower cytotoxicity, and excellent overall in vivo safety in early pre-clinical testing. | [Synthesis]
Maleic anhydride (MA) was added to a solvent mixture of cyclohexane and ethyl acetate in a polymerizer equipped with an agitator, a reflux condenser, and an inner temperature-controlling device. The polymerizer was purged of air and filled with nitrogen. The solution was heated to 70 °C, and then an initiator solution (lauroyl peroxide dissolved in ethyl acetate) and Methyl vinyl ether (MVE) were added to the polymerizer in a dropwise manner. A slurry was obtained, which was filtered and dried under a vacuum to obtain a white powdery copolymer. |
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| Company Name: |
Twochem Co.Ltd.
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| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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