| Identification | Back Directory | [Name]
DI-TERT-BUTYL HYDRAZODICARBOXYLATE | [CAS]
16466-61-8 | [Synonyms]
SKL269
N,N'-DI-BOC-HYDRAZINE
LABOTEST-BB LT00453977
di-tert-butyl bicarbamate
TERT-BUTYL HYDRAZODIFORMATE
DI-TERT-BUTYL HYDRAZODIFORMATE
DI-TERT-BUTYL HYDRAZODICARBOXYLATE
Di-tert-butyl hydrazodiformate 97%
Di-t-butylhydrazodicarboxylate-98%
DL-tert-Butyl Hydrazodicarboxylate
1,2-bis(t-butyloxycarbonyl)hydrazine
Di-tert-butylHydrazodicarboxylate>
n,n'-di-tert-butoxycarbonylhydrazine
1,2-Bis(tert-butoxycarbonyl)hydrazine
Di-tert-butyl hydrazodiformate
N,N'-Bis(tert-butoxycarbonyl)hydrazine
N,N'-Bi(carbamic acid tert-butyl) ester
Di-tert-butyl hydrazodicarboxylate, 98+%
Di-tert-butyl 1,2-Hydrazinedicarboxylate
Di-tert-butyl Hydrazodicarboxylate
di-tert-butyl hydrazine-1,2-dicarboxylate
Di-tert-butyl hydrazodicarboxylate≥ 98%(GC)
Hydrazine-1,2-dicarboxylic acid di-tert-butyl ester
Hydrazine-1,2-diylbis(formic acid tert-butyl) ester
N-(tert-butoxycarbonylamino)carbamic acid tert-butyl ester
1,2-Hydrazinedicarboxylic acid bis(1,1-dimethylethyl) ester
tert-butyl N-[(2-methylpropan-2-yl)oxycarbonylamino]carbamate
1,2-Hydrazinedicarboxylic acid, 1,2-bis(1,1-dimethylethyl) ester
N,N-Di-tert-butoxycarbonylhydrazine~Di-tert-butyl hydrazodiformate~Hydrazine-N,N-dicarboxylic acid di-tert-butyl est
N,N-Di-tert-butoxycarbonylhydrazine~Di-tert-butyl hydrazodiformate~Hydrazine-N,N-dicarboxylic acid di-tert-butyl ester | [EINECS(EC#)]
240-512-3 | [Molecular Formula]
C10H20N2O4 | [MDL Number]
MFCD00015000 | [MOL File]
16466-61-8.mol | [Molecular Weight]
232.28 |
| Chemical Properties | Back Directory | [Melting point ]
123-126 °C (dec.)(lit.)
| [Boiling point ]
294.6±9.0 °C(Predicted) | [density ]
1.064±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Powder or Crystalline Powder | [pka]
8.73±0.43(Predicted) | [color ]
White | [Water Solubility ]
Insoluble in water. | [BRN ]
1794023 | [InChI]
InChI=1S/C10H20N2O4/c1-9(2,3)15-7(13)11-12-8(14)16-10(4,5)6/h1-6H3,(H,11,13)(H,12,14) | [InChIKey]
TYSZETYVESRFNT-UHFFFAOYSA-N | [SMILES]
N(C(OC(C)(C)C)=O)NC(OC(C)(C)C)=O |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
Di-tert-butyl hydrazodiformate was used as starting reagent during the four-step synthesis of the aminobicyclopyrazolone hydrochloride. It was used as reagent during Pd-catalyzed amination reactions of halo-pyridine substrates. | [Uses]
Di-tert-butyl hydrazodicarboxylate, is used as starting reagent during the four-step synthesis of the aminobicyclopyrazolone hydrochloride. It was used as reagent during Pd-catalyzed amination reactions of halo-pyridine substrates. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 82, p. 2725, 1960 DOI: 10.1021/ja01496a018 | [General Description]
Di-tert-butyl hydrazodiformate acts as hydrazine substrate during the preparation of protected pyridylhydrazine derivatives. | [Synthesis]
General procedure for the synthesis of di-tert-butyl azodicarboxylate from di-tert-butyl dicarbonate: Hydrazine monohydrate (5.85 g, 85%, 200 mmol) was added dropwise to a methanol solution containing 50 ml of di-tert-butyl dicarbonate (48 g, 220 mmol) over a period of 30 min under ice bath cooling conditions. After the dropwise addition, the reaction mixture was stirred at room temperature for 3 hours. Subsequently, the methanol solvent was removed by rotary evaporator and 250 ml of n-hexane was added to the residue and the resulting white solid was collected by filtration and washed with n-hexane. A final white solid product of 19.34 g was obtained in 84% yield. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 20, p. 2715 - 2717
[2] Chemical Communications, 2011, vol. 47, # 1, p. 373 - 375
[3] Patent: CN104387418, 2016, B. Location in patent: Paragraph 0088; 0089; 0090
[4] Journal of the American Chemical Society, 2012, vol. 134, # 45, p. 18581 - 18584
[5] Patent: WO2014/22454, 2014, A1. Location in patent: Paragraph 0160 |
|
|