| Identification | More | [Name]
Methyl 5-thiazolecarboxylate | [CAS]
14527-44-7 | [Synonyms]
methyl 1,3-thiazole-5-carboxylate
METHYL 5-THIAZOLECARBOXYLATE
METHYL THIAZOLE-5-CARBOXYLATE
RARECHEM AL BF 1261
5-Thiazolecarboxylic acid, methyl ester | [Molecular Formula]
C5H5NO2S | [MDL Number]
MFCD03788563 | [Molecular Weight]
143.16 | [MOL File]
14527-44-7.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P271-P280 | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Harmful | [HS Code ]
2934100090 |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of methyl 5-thiazolecarboxylate from methyl 2-aminothiazole-5-carboxylate was as follows: a mixture of 2.25 g of isoamyl nitrite with 10 mL of dioxane was stirred at 80 °C under nitrogen protection. Subsequently, a 20 mL dioxane solution containing 1.23 g of methyl 2-aminothiazole-5-carboxylate (g-3) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was refluxed for 2 hours. After the reaction was completed, it was cooled to room temperature and diluted by adding 30 mL of ethyl acetate. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography to give 0.54 g (48% yield) of the target product methyl 5-thiazolecarboxylate (g-4). | [References]
[1] Patent: WO2003/97616, 2003, A1. Location in patent: Page/Page column 26 |
|
|