| Identification | Back Directory | [Name]
5'-Adenylic acid, 2-(propylthio)-, anhydride with P,P'-(dichloromethylene)bis[phosphonic acid] (1:1) | [CAS]
164992-25-0 | [Synonyms]
PSB0413
5'-Adenylic acid, 2-(propylthio)-, anhydride with P,P'-(dichloromethylene)bis[phosphonic acid] (1:1) | [Molecular Formula]
C14H22Cl2N5O12P3S | [MOL File]
164992-25-0.mol | [Molecular Weight]
648.23 |
| Hazard Information | Back Directory | [Description]
AR-C67085 is a ADP receptor antagonist on the TIPA inhibition. | [Uses]
AR-C67085 (PSB 0413; FPL 67085) is a potent platelet P2T receptor antagonist with an pIC50 value of 8.60. AR-C67085 inhibits ADP-induced platelet aggregation[1][2]. | [References]
[1] Humphries RG, et al. A novel series of P2T purinoceptor antagonists: definition of the role of ADP in arterial thrombosis. Trends Pharmacol Sci. 1995 Jun;16(6):179-81. DOI:10.1016/s0165-6147(00)89018-5
[2] Ingall AH, et al. Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy. J Med Chem. 1999 Jan 28;42(2):213-20. DOI:10.1021/jm981072s |
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