| Identification | Back Directory | [Name]
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH | [CAS]
1662688-20-1 | [Synonyms]
Octa(OtBu)-Glu(ɑ-OtBu)-AEEA-AEEA-OH
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH
Fmoc-Lys(tBu-OOC-C16-CO-Glu(AEEA-AEEA)-OtBu)-OH
22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic acid
11,14,20,23-Tetraoxa-2,8,17,26,31-pentaazanonatetracontanedioic acid, 3-carboxy-30-[(1,1-dimethylethoxy)carbonyl]-9,18,27,32-tetraoxo-, 49-(1,1-dimethylethyl) 1-(9H-fluoren-9-ylmethyl) ester,
11,14,20,23-Tetraoxa-2,8,17,26,31-pentaazanonatetracontanedioic acid, 3-carboxy-30-[(1,1-dimethylethoxy)carbonyl]-9,18,27,32-tetraoxo-, 49-(1,1-dimethylethyl) 1-(9H-fluoren-9-ylmethyl) ester, (3S,30S)- | [Molecular Formula]
C64H101N5O16 | [MDL Number]
MFCD34563738 | [MOL File]
1662688-20-1.mol | [Molecular Weight]
1196.51 |
| Chemical Properties | Back Directory | [Boiling point ]
1215.5±65.0 °C(Predicted) | [density ]
1.130±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: Soluble: =10 mg/ml
Ethanol: Soluble: =10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml | [form ]
Liquid
(Density: 1.130±0.06 g/cm3) | [pka]
3.87±0.21(Predicted) | [color ]
Colorless to light yellow | [InChIKey]
COTQASXXEXJBOM-PJYGOTMFSA-N | [SMILES]
C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)N[C@H](C(O)=O)CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](C(OC(C)(C)C)=O)NC(=O)CCCCCCCCCCCCCCCCC(OC(C)(C)C)=O |
| Hazard Information | Back Directory | [Description]
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH (CAS 1662688-20-1, purity 99%), also known as the semaglutide side chain, is the core building block of the antidiabetic and weight-loss drug semaglutide. Semaglutide is a glucagon-like peptide-1 receptor (GLP-1R) agonist, primarily used for the treatment of type 2 diabetes, chronic weight management and the reduction of the risk of major cardiovascular events. It works by mimicking a natural hormone to suppress appetite, slow digestion and regulate blood glucose levels. | [Uses]
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH is a useful compound in the chemical research. | [Definition]
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH is a useful research chemical used in the preparation of semaglutide. Reagent grade, for research purpose.
| [References]
[1] IVAN GURYANOV*. Copper(II) Lysinate and Pseudoproline Assistance in the Convergent Synthesis of the GLP-1 Receptor Agonists Liraglutide and Semaglutide[J]. Organic Process Research & Development, 2021, 25 7: 1598-1611. DOI: 10.1021/acs.oprd.1c00021 |
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Abydos Scientific Gold
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