| Identification | More | [Name]
gamma-Benzyl L-glutamate | [CAS]
1676-73-9 | [Synonyms]
GAMA-BENZYL L-GLUTAMATE
GAMMA-BENZYL-L-GLUTAMATE
GLU(OBZL)
GLUTAMIC ACID-GAMMA-BENZYL ESTER
GLUTAMIC ACID(OBZL)-OH
H-GLU(OBZL)-OH
H-L-GLU(BZL)-OH
H-L-GLU(OBZL)-OH
L-GAMMA-BENZYL GLUTAMATE
L-GLUTAMIC ACID 5-BENZYL ESTER
L-GLUTAMIC ACID BENZYL ESTER
L-GLUTAMIC ACID GAMMA-BENZYL ESTER
d-glutamicacid5-benzylester
l-glutamicacid,5-(phenylmethyl)ester
benzyl hydrogen gamma-L-glutamate
Glu(OBzl)-OH
L-Glutamic acid g-benzyl ester
H-GLU(OBZL)-OH, L-GLUTAMIC ACID GAMMA-BENZYL ESTER
gamma-Benzyl L-glutamate, 99+%
gamma-benzyl l-glutamat | [EINECS(EC#)]
216-826-1 | [Molecular Formula]
C12H14NO4- | [MDL Number]
MFCD00002633 | [Molecular Weight]
236.24 | [MOL File]
1676-73-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
181-182 °C(lit.)
| [alpha ]
27.2 º (c=2, 1N HCL) | [Boiling point ]
379.78°C (rough estimate) | [density ]
1.2026 (rough estimate) | [refractive index ]
1.5200 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Acetic Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated, Son | [form ]
Powder | [pka]
2.20±0.10(Predicted) | [color ]
White | [Optical Rotation]
[α]20/D +19±2°, c = 1% in acetic acid | [BRN ]
1885646 | [InChI]
InChI=1S/C12H15NO4/c13-10(12(15)16)6-7-11(14)17-8-9-4-2-1-3-5-9/h1-5,10H,6-8,13H2,(H,15,16)/t10-/m0/s1 | [InChIKey]
BGGHCRNCRWQABU-JTQLQIEISA-N | [SMILES]
C(O)(=O)[C@H](CCC(OCC1=CC=CC=C1)=O)N | [CAS DataBase Reference]
1676-73-9(CAS DataBase Reference) | [EPA Substance Registry System]
1676-73-9(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
IRRITANT | [HS Code ]
29224999 |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
L-Glutamic acid γ-benzyl ester is commonly used in the synthesis of polymers for biological applications. Some of the examples are:
- Synthesis of bioreducible block copolymers based on poly(ethylene glycol) and poly(γ-benzyl L-glutamate) for Intracellular drug delivery.
- Synthesis of biodegradable poly(L-glutamic acid)-b-polylactide for magnetic resonance imaging (MRI)-visible drug delivery system.
- Synthesis of pH and temperature-responsive diblock copolymers based on poly(L-glutamic acid).
| [reaction suitability]
reaction type: solution phase peptide synthesis | [Purification Methods]
Recrystallise the ester from H2O and store it at 0o. [Estrin Biochemical Preparations 13 25 1971, Beilstein 6 IV 2538.] |
|
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