| Identification | Back Directory | [Name]
ELEUTHEROSIDE B1(RG) | [CAS]
16845-16-2 | [Synonyms]
ELEUTHEROSIDE B1(RG)
2H-1-Benzopyran-2-one,7-(a-D-glucopyranosyloxy)-6,8-dimethoxy-
2H-1-Benzopyran-2-one, 7-(α-D-glucopyranosyloxy)-6,8-dimethoxy- | [Molecular Formula]
C17H20O10 | [MOL File]
16845-16-2.mol | [Molecular Weight]
384.34 |
| Chemical Properties | Back Directory | [Boiling point ]
675.0±55.0 °C(Predicted) | [density ]
1.524±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
12.65±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in chloroform, derived from the dried rhizome of Acanthopanax senticosus. | [Uses]
Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50?value of 64-125?μg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities[1]. | [Biological Activity]
Eleutheroside B1, a coumarin compound, has broad-spectrum anti-human influenza virus (influenza virus) activity with IC50 values of 64-125μg/ml. It mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits mRNA expression of multiple chemokine genes and influenza virus nucleoprotein (NP) gene with low cytotoxicity. Has antiviral and anti-inflammatory activity. | [in vitro]
Eeutheroside B1 (100 μg/ml; 24 hours) influences mRNA expression of host genes and virus genes in A549 cells. RT-PCR | Cell Line: | Virus-infected A549 cells | | Concentration: | 100 μg/ml | | Incubation Time: | 24 hours | | Result: | The expression of host genes (MAN2A2, POLR2A) and virus genes (PA, PB1, PB2, HA) were decreased. | | [References]
[1] Yan W, et al. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation.Int J Mol Med.?2018?Nov;42(5):2776-2792. DOI:10.3892/ijmm.2018.3863 |
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