| Identification | More | [Name]
(S)-1-Boc-2-benzylpiperazine | [CAS]
169447-86-3 | [Synonyms]
2S-BENZYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S)-1-N-BOC-2-BENZYL-PIPERAZINE
(S)-2-BENZYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S)-N1-BOC-2-BENZYLPIPERAZINE
(S)-1-Boc-2-benzyl-piperazine
(S)-1-Boc-2-Benzylpiperizine
(S)-1-BOC-2-BENZYL-PIPERAZINE 98%
(S)-2-Benzylpiperazine, N1-BOC protected
(S)-tert-Butyl 2-benzylpiperazine-1-carboxylate | [Molecular Formula]
C16H24N2O2 | [MDL Number]
MFCD03787923 | [Molecular Weight]
276.37 | [MOL File]
169447-86-3.mol |
| Questions And Answer | Back Directory | [Preparation]
2-Benzylpiperazine and 200 mL of a buffer solution consisting of sodium carbonate and sodium bicarbonate were added to a three-necked flask equipped with a stirrer. The mixture was placed in an ice bath, and tert-butyl dicarbonate was added dropwise using a dropping funnel. The reaction mixture was stirred in a water bath at 30°C for 22 hours. The reactants were extracted with diethyl ether (100 mL × 2) to remove unreacted tert-butyl dicarbonate. The resulting aqueous phase was adjusted to pH 2-3 with 3 mol/L hydrochloric acid solution, then extracted with ethyl acetate (100 mL × 4), dried over anhydrous sodium sulfate, filtered, and the solvent was removed by rotary evaporation to obtain a colorless oily liquid (S)-1-Boc-2-benzylpiperazine. | [Uses]
(S)-1-Boc-2-benzylpiperazine is an important intermediate in the synthesis of many drugs. |
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