ChemicalBook--->CAS DataBase List--->173399-03-6

173399-03-6

173399-03-6 Structure

173399-03-6 Structure
IdentificationBack Directory
[Name]

(2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride
[CAS]

173399-03-6
[Synonyms]

Aliskiren HCl
Rasilez Hydrochloride
Tekturna Hydrochloride
Aliskiren Hydrochloride
(2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride
(αS,γS,δS,zS)-δ-AMino-N-(3-aMino-2,2-diMethyl-3-oxopropyl)-γ-hydroxy-4-Methoxy-3-(3-Methoxypropoxy)-α,z-bis(1-Methylethyl)benzeneoctanaMide Hydrochloride
(2S,4S,5S,7S)-5-AMino-N-(3-aMino-2,2-diMethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-Methoxy-3-(3-Methoxypropoxy)benzyl)-8-MethylnonanaMide hydrochloride
[Molecular Formula]

C30H54ClN3O6
[MDL Number]

MFCD13185885
[MOL File]

173399-03-6.mol
[Molecular Weight]

588.23
Chemical PropertiesBack Directory
[Melting point ]

76-78°C
[storage temp. ]

Hygroscopic, -20°C Freezer, Under Inert Atmosphere
[solubility ]

Chloroform, Methanol
[form ]

Solid
[color ]

White to Pale Yellow
[Stability:]

Hygroscopic
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Uses]

An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.
[in vivo]

Aliskiren hydrochloride (3 mg/kg, 10 mg/kg; p.o.; daily; 0-12 d) inhibit renin and lower blood pressure without affecting heart rate in sodium-depleted marmosets[3].
Aliskiren hydrochloride (10 mg/kg; p.o.; single dose) delays cachexia development, reduces tumor, and prolongs mouse survival. And also improves whole body strength, mobility and coordination, enhances locomotor activity, and inhibits muscle wasting[4].
Aliskiren hydrochloride (10 mg/kg; p.o.; single dose; 20 d after C26 injection) reduces oxidative stress associated with cancer cachexia[4].

Animal Model:Sodium-depleted marmosets[3]
Dosage:3 mg/kg, 10 mg/kg
Administration:Oral gavage; once daily; 12 days
Result:Increased plasma immunoreactive renin levels, and lowered blood pressure without affecting heart rate.
Showed no rebound increase in BP following the end of treatment with either dose of aliskiren.
Inhibited the RAS and controls the upregulation of pro?inflammatory cytokines.
Animal Model:Cancer cachexia model in BALB/c mice injected with C26 mouse colon carcinoma cells[4]
Dosage:10 mg/kg
Administration:Oral gavage; on day 5 (as a preventive strategy, AP group) or on day 12 (as a therapeutic strategy, AT group) after C26 injection; for 20 days after C26 injection
Result:Enhanced grip strength, coordination, and locomotor activity.
Inhibited serum Ang I and Ⅱ levels and both serum and muscular tumor necrosis factor?α (TNF?α) and inter? leukin?6 (IL?6) levels.
173399-03-6 suppliers list
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Website: www.chemicalbook.com/ShowSupplierProductsList454175/0.htm
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135 , +8613564774135
Website:
Company Name: J & K SCIENTIFIC LTD.  
Tel: 18210857532 18210857532
Website: www.jkchemical.com
Company Name: Chemsky(shanghai)International Co.,Ltd.  
Tel: 021-50135380
Website: www.shchemsky.com
Company Name: Cato Research Chemicals Inc.  
Tel: 020-81960175
Website: www.cato-chem.com
Company Name: Nanjing XiZe Biotechnology CO., Ltd.  
Tel: 025-66023220 0086-15250997978
Website: http://www.njxizebio.com
Company Name: Raw material medicin reagent co.,Ltd  
Tel:
Website: http://www.njromanme.com
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
Tel: +86-400-002-6226 +86-13028896684;
Website: https://www.rrkchem.com
Company Name: Energy Chemical  
Tel: 021-58432009 400-005-6266
Website: http://www.energy-chemical.com
Company Name: Wuhan Yanzhe Technology Co., Ltd  
Tel: 15527250409
Website: https://www.chemicalbook.com/Supplier/23754455/
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Santa Cruz Biotechnology Inc  
Tel: 60936350
Website: http://www.scbt.com
Company Name: Carbosynth  
Tel: +86 512 6260 5585
Website: www.carbosynth.com
Company Name: Alfa Chemistry   
Tel: +1 (201) 478-8534
Website: www.alfa-chemistry.com
Company Name: Toronto Research Chemicals  
Tel: +1 (416) 665-9696
Website: www.trc-canada.com
Company Name: Aurora Fine Chemicals Ltd.  
Tel: [43] 316586738
Website: www.aurorafinechemicals.com
Company Name: Santa Cruz Biotechnology, Inc.   
Tel: +1 (831) 457-3800
Website: www.scbt.com
Tags:173399-03-6 Related Product Information
104-94-9 60-32-2 456-55-3 150-76-5 77-86-1 90-05-1 56-40-6 123-11-5 104-47-2 100-66-3

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.