| Identification | Back Directory | [Name]
2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide, compound with 4-butyl-1,2-diphenyltetrahydropyrazol-3,5-dione (1:1) | [CAS]
17449-96-6 | [Synonyms]
Panas
Clofezon
ANP-3260
CBOFEZONE
Clofezonum
Perclusone
Clofexamide-phenylbutazone
2-(4-Chlorophenoxy)-N-(2-(diethylamino)ethyl)acetamide compound with 4-butyl-1,2-diphenylpyrazolidine-3,5-dione (1:1)
2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide, compound with 4-butyl-1,2-diphenyltetrahydropyrazol-3,5-dione (1:1) | [EINECS(EC#)]
241-466-7 | [Molecular Formula]
C33H41ClN4O4 | [MDL Number]
MFCD01733757 | [MOL File]
17449-96-6.mol | [Molecular Weight]
593.17 |
| Hazard Information | Back Directory | [Originator]
Perclusone,Anphar-Rolland,France,1967 | [Uses]
Clofezone (Perclusone) is an antirheumatic agent that inhibits collagen formation in rat Chondrus granulomas. Clofezone can be used in the study of various rheumatic diseases, especially arthritis (RA) and ankylosing spondylitis (AS)[1][2]. | [Manufacturing Process]
935 g of phenylbutazone are dissolved, with heating to a lukewarm state, in
2.7 liters of acetone containing 20% water, and the mixture is filtered if
necessary. 853.5 g of p-chlorophenoxyacetic acid diethylamino ethylamide are
dissolved in 300 cc of acetone containing 20% water, and the solution is
poured into the phenylbutazone solution. There is slight heating, and the
solution clarifies. The salt crystallizes rapidly. Drying is effected on a Buchner
funnel and the mixture is washed in 450 cc of acetone containing 20% of
water. The 1,702 g of product obtained is recrystallized in 2,450 cc of acetone
containing 20% of water and, after drying in an oven at 37°C, 1,585 g (86%)
of product are obtained. The product is in the form of a white crystalline
powder having a melting point of from 87° to 89°C in the Maquenne block. | [Therapeutic Function]
Analgesic, Antiinflammator | [References]
[1] Brettschneider I, et al. Effect of some antirheumatics on connective tissue components. Arzneimittelforschung. 1976;26(5):846-8. PMID:134719
[2] Celik CM. Erfahrungen in der Behandlung rheumatoider Erkrankungen mit unterschiedlichen Clofezon-Dosen [Experiences in the management of rheumatoid diseases using different clofezone doses]. Z Rheumatol. 1976 May-Jun;35(5-6):240-7. PMID:133565 |
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