| Identification | Back Directory | [Name]
METHYL 2-METHYL-5-FLUOROBENZOATE | [CAS]
175278-29-2 | [Synonyms]
RARECHEM AL BF 0505
5-fluoro-2-methylbenzoate
METHYL 2-METHYL-5-FLUOROBENZOATE
METHYL 5-FLUORO-2-METHYLBENZOATE
Benzoic acid, 5-fluoro-2-methyl-, methyl ester | [Molecular Formula]
C9H9FO2 | [MDL Number]
MFCD00221457 | [MOL File]
175278-29-2.mol | [Molecular Weight]
168.16 |
| Chemical Properties | Back Directory | [Boiling point ]
90-92°C 15mm | [density ]
1.137±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
liquid | [color ]
Brown |
| Hazard Information | Back Directory | [Uses]
Methyl 5-fluoro-2-methylbenzoate was used for the preparation of derivatives of piperidinedione.
| [Synthesis]
5-Fluoro-2-methylbenzoic acid (2.3 g) was dissolved in tetrahydrofuran (THF, 50 ml). To the solution, iodomethane (0.95 ml) and N,N-diisopropylethylamine (3.2 ml) were added sequentially. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was filtered and the filtrate concentrated to give methyl 5-fluoro-2-methylbenzoate (2.3 g; 90% yield).1H-NMR (CDCl3) δ: 2.6 (s, 3H), 3.9 (s, 3H), 7.0-7.2 (m, 2H), 7.6-7.7 (m, 1H). | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5286 - 5289
[2] Patent: WO2006/116157, 2006, A2. Location in patent: Page/Page column 83-84 |
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