| Identification | More | [Name]
5-Fluoro-2-methoxyphenol | [CAS]
72955-97-6 | [Synonyms]
4-fluoro-2-hydroxyanisole
5-FLUORO-2-METHOXYPHENOL
5-fluoro-2-metoxyphenol
5-Fluoro-2-methoxyphenol98%
2-Hydroxy-4-fluoroanisole | [Molecular Formula]
C7H7FO2 | [MDL Number]
MFCD00143459 | [Molecular Weight]
142.13 | [MOL File]
72955-97-6.mol |
| Chemical Properties | Back Directory | [Boiling point ]
223°C | [density ]
1.224 | [Fp ]
111°C | [storage temp. ]
Sealed in dry,2-8°C | [form ]
liquid | [pka]
8.97±0.10(Predicted) | [color ]
Clear | [InChI]
InChI=1S/C7H7FO2/c1-10-7-3-2-5(8)4-6(7)9/h2-4,9H,1H3 | [InChIKey]
PPJKLEQAFZWIQY-UHFFFAOYSA-N | [SMILES]
C1(O)=CC(F)=CC=C1OC | [CAS DataBase Reference]
72955-97-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P260-P280 | [Hazard Codes ]
C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
WGK 3 | [Hazard Note ]
Irritant | [HS Code ]
2909500090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Questions And Answer | Back Directory | [Application]
5-Fluoro-2-methoxyphenol is an important pesticide and pharmaceutical intermediate. It can be synthesized from methyl ether using butyllithium and trimethoxyboron in the presence of butyllithium and trimethoxyboron. It is used to synthesize alicylates, a drug for treating hypertension. |
| Hazard Information | Back Directory | [Synthesis]
In a 500 mL four-necked flask add 150 g (0.9 mol) acetyl guaiacol, glacial acetic acid 240 mL, iodine 2.5 g (0.01 mol) at 25 ° C, stirring dropwise addition of liquid bromine 160 g (2 mol), dropwise addition is complete, heated to 100 ° C reaction for 10 |
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