| Identification | More | [Name]
Propitocaine hydrochloride | [CAS]
1786-81-8 | [Synonyms]
2-(propylamino)-o-propionotoluidide hydrochloride
N-(2-METHYLPHENYL)-2-(PROPYLAMINO)PROPANAMIDE HYDROCHLORIDE
PRILOCAINE HCL
PRILOCAINE HYDROCHLORIDE
propitocaine hydrochloride
2-(propylamino)-o-propionotoluididmonohydrochloride
alpha-propylamine-2-methyl-propionanilidehydrochloride
citanesthydrochloride
l-67hydrochloride
n-(2-methylphenyl)-2-(propylamino)-propanamidmonohydrochloride
prilocainechloride
xylonest
PRILOCAINE HYDROCHLORIDE USP
PRILOCAINE HYDROCHLORIDE ASSAY STANDARD BP(CRM STANDARD)
PRILOCAINE HYDROCHLORIDE BP STANDARD
PRILOCAINE HYDROCHLORIDE BP STANDARD(CRM STANDARD)
PRILOCAINE HYDROCHLORIDE EPP
PRILOCAINE HYDROCHLORIDE EPP(CRM STANDARD)
PRILOCAINE HYDROCHLORIDE MM
PRILOCAINE HYDROCHLORIDE MM(CRM STANDARD) | [EINECS(EC#)]
217-244-0 | [Molecular Formula]
C13H21ClN2O | [MDL Number]
MFCD00079279 | [Molecular Weight]
256.77 | [MOL File]
1786-81-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
168-170°C | [storage temp. ]
Refrigerator | [solubility ]
Freely soluble in water and in ethanol (96 per cent), very slightly soluble in acetone | [form ]
neat | [color ]
White to Off-White | [Merck ]
14,7743 | [InChI]
InChI=1S/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1H | [Contact allergens]
Prilocaine in a local anesthetic of the amide group. It
can induce allergic contact dermatitis, particularly
from EMLA® cream. | [InChIKey]
BJPJNTKRKALCPP-UHFFFAOYSA-N | [SMILES]
C1(=CC=CC=C1C)NC(=O)C(C)NCCC.Cl | [CAS DataBase Reference]
1786-81-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Anesthetic (local). | [Uses]
antibacterial | [Uses]
Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/pril
ocaine or EMLA), for treatment of conditions like paresthesia. | [Definition]
ChEBI: The monohydrochloride salt of prilocaine. | [Brand name]
Citanest (AstraZeneca). | [Biological Functions]
Prilocaine hydrochloride (Citanest) is an amide
anesthetic whose onset of action is slightly longer than
that of lidocaine; its duration of action is comparable.
Prilocaine is 40% less toxic acutely than lidocaine, making
it especially suitable for regional anesthetic techniques.
It is metabolized by the liver to orthotoluidine,
which when it accumulates, can cause conversion of hemoglobin
(HB+++ to methemoglobin (HB+++. Oxygen
transport is impaired in the presence of methemoglobinemia.
Treatment involves the use of reducing agents,
such as methylene blue, given intravenously, to reconvert
methemoglobin to hemoglobin. | [Side effects]
Common adverse reactions include bradycardia, hypotension, urticaria, edema, anaphylactoid reactions, lightheadedness, nervousness, euphoria, confusion, dizziness, drowsiness, tinnitus. The safety and effectiveness of prilocaine depend on proper dosage, correct technique, adequate precautions, and readiness for emergencies.
| [storage]
Store at -20°C |
| Safety Data | Back Directory | [WGK Germany ]
3 | [RTECS ]
UG5775000 | [HS Code ]
29242990 | [Toxicity]
man,LDLo,parenteral,12343ug/kg/1H (12.343mg/kg),BLOOD: HEMORRHAGE,Journal of Analytical Toxicology. Vol. 10, Pg. 75, 1986. |
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