| Identification | Back Directory | [Name]
QX77 | [CAS]
1798331-92-6 | [Synonyms]
QX77
CMA activator
CMA ACTIVATOR;QX77;QX-77;QX 77
Acetamide, N-[4-(7-chloro-2H-1,4-benzoxazin-3-yl)phenyl]- | [Molecular Formula]
C16H13ClN2O2 | [MDL Number]
MFCD31657441 | [MOL File]
1798331-92-6.mol | [Molecular Weight]
300.74 |
| Chemical Properties | Back Directory | [Boiling point ]
514.5±50.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 25mg/mL; DMF:PBS (pH 7.2) (1:2): 0.3mg/mL; DMSO: 15mg/mL | [form ]
A solid | [pka]
14?+-.0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells[1]. QX77 can impede self-renewal and promote differentiation of ES cells[2]. | [Biological Activity]
QX77 is a chaperone-mediated autophagy (CMA) activator derived from the atypical retinoid AR7 th at activates CMA by antagonizing retinoic acid receptor-α (RARα) signaling. QX77 rescues defective trafficking & lysosomal localization of the CMA receptor LAMP2A in cystinotic Ctns-/- MEFs and CTNS-KO human proximal tubule cells (PTCs) by restoring Rab11 expression and Rab11-positive vesicles trafficking to the level seen in wild-type cells (20 μM48 hrs). CMA activation by QX77 treatment (20 μM5 days) also significantly reduces toxic α-synuclein (α-syn) accumulation in PD patients iPSCs-derived astrocytes with LRRK2 G2019S mutation. | [storage]
Store at -20°C | [References]
[1] Jinzhong Zhang, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346 DOI:10.1074/jbc.M116.764076
[2] Yi Xu, et al. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 Jul 24;369(6502):397-403. DOI:10.1126/science.abb4467 |
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| Company Name: |
Twochem Co.Ltd.
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| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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