| Identification | Back Directory | [Synonyms]
COOH-PEG6-COOMe
Acid-PEG6-mono-methyl ester
3-[2-[2-[2-[2-[2-(3-methoxy-3-oxopropoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| Chemical Properties | Back Directory | [Boiling point ]
503.7±50.0 °C(Predicted) | [density ]
1.147±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
4.28±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Acid-PEG6-mono-methyl ester is a PEG linker containing a terminal carboxylic acid and a methyl ester group. The carboxylic acid can react with primary amine groups in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of a compound in aqueous media. The water solubility properties of the PEG chain are enhanced with longer PEG chains. | [Uses]
Acid-PEG6-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Borenpharm Co., Ltd
|
| Telephone: |
027-65563561 18717150066 |
| Website: |
www.borenpharm.com |
| Company Name: |
Nextpeptide Inc
|
| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
|