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1835759-79-9

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1835759-79-9 Structure

1835759-79-9 Structure
IdentificationBack Directory
[Name]

Acid-PEG3-NHS ester
[CAS]

1835759-79-9
[Synonyms]

COOH-PEG3-NHS
COOH-PEG3-SPA
Acid-PEG3-NHS ester
Acid-C2-PEG3-NHS ester
Propanoic acid, 3-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]-, 1-(2,5-dioxo-1-pyrrolidinyl) ester
[Molecular Formula]

C14H21NO9
[MDL Number]

MFCD29052171
[MOL File]

1835759-79-9.mol
[Molecular Weight]

347.32
Chemical PropertiesBack Directory
[Boiling point ]

516.1±60.0 °C(Predicted)
[density ]

1.34±0.1 g/cm3(Predicted)
[solubility ]

Soluble in DMSO, DCM, DMF
[pka]

4.28±0.10(Predicted)
Hazard InformationBack Directory
[Description]

Acid-PEG3-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
[Uses]

Acid-C2-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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