| Identification | Back Directory | [Name]
Mal-PEG1-NHS ester | [CAS]
1807518-72-4 | [Synonyms]
Mal-PEG1-SPA
CAS_1807518-72-4
Mal-PEG1-NHS ester
2,5-Dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate
Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C13H14N2O7 | [MDL Number]
MFCD26127783 | [MOL File]
1807518-72-4.mol | [Molecular Weight]
310.26 |
| Chemical Properties | Back Directory | [Boiling point ]
488.4±55.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DCM | [form ]
Solid | [pka]
-2.35±0.20(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C13H14N2O7/c16-9-1-2-10(17)14(9)6-8-21-7-5-13(20)22-15-11(18)3-4-12(15)19/h1-2H,3-8H2 | [InChIKey]
AMRJPIJPLBUEHO-UHFFFAOYSA-N | [SMILES]
C(ON1C(=O)CCC1=O)(=O)CCOCCN1C(=O)C=CC1=O |
| Hazard Information | Back Directory | [Description]
Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Biological Activity]
Mal-PEG1-NHS ester is a cleavable PEG-based ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PEG-based PROTAC linker that can be used to synthesize PROTACs. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
|
| Company Name: |
T&W GROUP
|
| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
| Company Name: |
Henan Alfachem Co.,Ltd.
|
| Telephone: |
0371-55051623 18137891487 |
| Website: |
www.chemicalbook.com/supplier/14555231/ |
| Company Name: |
Nextpeptide Inc
|
| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
|
|
Tags:1807518-72-4
Related Product Information
|
|
518044-36-5
1325208-25-0
1599472-25-9
518044-35-4
1537892-36-6
518044-42-3
1008402-47-8
518044-37-6
518044-40-1
146551-23-7
119039-87-1
25322-68-3
1807530-08-0
2055041-37-5
2249935-92-8
|
|