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1807518-72-4

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1807518-72-4 Structure

1807518-72-4 Structure
IdentificationBack Directory
[Name]

Mal-PEG1-NHS ester
[CAS]

1807518-72-4
[Synonyms]

Mal-PEG1-SPA
CAS_1807518-72-4
Mal-PEG1-NHS ester
2,5-Dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate
Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
[Molecular Formula]

C13H14N2O7
[MDL Number]

MFCD26127783
[MOL File]

1807518-72-4.mol
[Molecular Weight]

310.26
Chemical PropertiesBack Directory
[Boiling point ]

488.4±55.0 °C(Predicted)
[density ]

1.48±0.1 g/cm3(Predicted)
[solubility ]

Soluble in DCM
[pka]

-2.35±0.20(Predicted)
Hazard InformationBack Directory
[Description]

Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
[Biological Activity]

Mal-PEG1-NHS ester is a cleavable PEG-based ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[target]

Cleavable

PEGs

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