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1809427-19-7

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1809427-19-7 Structure

1809427-19-7 Structure
IdentificationBack Directory
[Name]

DT-061
[CAS]

1809427-19-7
[Synonyms]

Benzenesulfonamide, N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)-
[Molecular Formula]

C25H23F3N2O5S
[MDL Number]

MFCD31813712
[MOL File]

1809427-19-7.mol
[Molecular Weight]

520.52
Chemical PropertiesBack Directory
[Boiling point ]

625.5±65.0 °C(Predicted)
[density ]

1.51±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 125 mg/mL (240.14 mM);Water : < 0.1 mg/mL (insoluble)
[form ]

Solid
[pka]

10.48±0.60(Predicted)
[color ]

Off-white to light yellow
[SMILES]

O[C@H]1[C@@H](CCC[C@@H]1N2C3=C(OC4=C2C=CC=C4)C=CC=C3)NS(C5=CC=C(C=C5)OC(F)(F)F)(=O)=O
Hazard InformationBack Directory
[Uses]

DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis[1].
[in vivo]

DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient[1].

Animal Model:6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106)[1].
Dosage:5 mg/kg.
Administration:Oral gavage for 4 weeks.
Result:Showed activity in inhibiting tumor growth.
[storage]

Store at -20°C
[References]

[1] Kauko O, et al. PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. DOI:10.1126/scitranslmed.aaq1093
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