| Identification | Back Directory | [Name]
THIAZOLIUM, 4,5-DIMETHYL-3-(2-OXO-2-PHENYLETHYL)-, BROMIDE | [CAS]
181069-80-7 | [Synonyms]
Alagebrium bromide
THIAZOLIUM, 4,5-DIMETHYL-3-(2-OXO-2-PHENYLETHYL)-, BROMIDE | [Molecular Formula]
C13H14BrNOS | [MOL File]
181069-80-7.mol | [Molecular Weight]
312.225 |
| Hazard Information | Back Directory | [Description]
Alagebrium is an advanced glycation endproducts (AGE) cross-link breaker. | [Uses]
Alagebrium bromide is an analog of Alagebrium Chloride (HY-106024B), a glucose cross-link blocker. Alagebrium Chloride disrupts glucose cross-links and may improve ventricular and arterial compliance. Alagebrium Chloride improves left ventricular diastolic filling and has the potential to inhibit diastolic heart failure (DHF). | [References]
[1] Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C-α?Dependent Pathway |
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