| Identification | Back Directory | [Name]
CU-3
(DGKα inhibitor CU-3) | [CAS]
1815598-71-0 | [Synonyms]
(5Z,2E)-CU-3
DGKα inhibitor CU-3
CU-3
(DGKα inhibitor CU-3)
Benzenesulfonamide, N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]- | [Molecular Formula]
C16H12N2O4S3 | [MDL Number]
MFCD05683563 | [MOL File]
1815598-71-0.mol | [Molecular Weight]
392.47 |
| Chemical Properties | Back Directory | [Boiling point ]
561.8±60.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 20 mg/mL (50.96 mM; ultrasonic and warming and heat to 60°C) | [form ]
A solid | [pka]
4.72±0.20(Predicted) | [color ]
Yellow to brown | [Water Solubility ]
Water: < 0.1 mg/mL (insoluble) |
| Hazard Information | Back Directory | [Uses]
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1]. | [References]
[1] Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79. DOI:10.1194/jlr.M062794 |
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| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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