| Identification | Back Directory | [Name]
LL Z1640-2 | [CAS]
253863-19-3 | [Synonyms]
C 292
FR148083
L 783279
f 152 A1
TAK1 inhibitor 5ZO)
5Z-7-Oxozeaenol >=98% (HPLC)
1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-
(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione | [Molecular Formula]
C19H22O7 | [MDL Number]
MFCD12912700 | [MOL File]
253863-19-3.mol | [Molecular Weight]
362.37 |
| Chemical Properties | Back Directory | [Melting point ]
171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3)) | [Boiling point ]
666.8±55.0 °C(Predicted) | [density ]
1.270±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL | [form ]
powder | [pka]
7.32±0.70(Predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Uses]
LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models. | [Definition]
ChEBI: 5Z-7-oxozeaenol is a macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB. It has a role as a metabolite, an antibacterial agent, an antineoplastic agent and a NF-kappaB inhibitor. It is an aromatic ether, a macrolide, a member of phenols, a secondary alcohol and a secondary alpha-hydroxy ketone. | [Biochem/physiol Actions]
The anti-inflammatory effects of 5Z-7-oxozeaenol may affect cardiac hypertrophy. | [IC 50]
TAK1: 8.1 nM (IC50); MEK1: 411 nM (IC50); VEGFR-2: 52 nM (IC50); VEGFR-3: 110 nM (IC50); FLT3: 170 nM (IC50); PDGFR-β: 340 nM (IC50); B-RAF VE: 6300 nM (IC50); SRC: 6600 nM (IC50) | [storage]
Desiccate at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
|