| Identification | Back Directory | [Name]
N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE | [CAS]
182073-77-4 | [Synonyms]
ZD8321
N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE
L-Prolinamide, N-(methoxycarbonyl)-L-valyl-N-[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]- | [Molecular Formula]
C18H28F3N3O5 | [MDL Number]
MFCD00949903 | [MOL File]
182073-77-4.mol | [Molecular Weight]
423.43 |
| Chemical Properties | Back Directory | [Boiling point ]
573.9±50.0 °C(Predicted) | [density ]
1.232±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
11.22±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki of 13±1.7 nM. | [Biological Activity]
ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki value of 13±1.7 nM. | [in vitro]
TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. | [target]
Ki: 13±1.7 nM (Neutrophil elastase) | [storage]
Store at -20°C | [References]
[1] Veale CA, et al. Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase. J Med Chem. 1997 Sep 26;40(20):3173-81. DOI:10.1021/jm970250z
[2] Nozawa F, et al. Elastase activity enhances the adhesion of neutrophil and cancer cells to vascular endothelial cells. J Surg Res. 2000 Dec;94(2):153-8. DOI:10.1006/jsre.2000.6002 |
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