| Identification | Back Directory | [Name]
cPrPMEDAP | [CAS]
182798-83-0 | [Synonyms]
cPrPMEDAP
Phosphonic acid, P-[[2-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]ethoxy]methyl]- | [Molecular Formula]
C11H17N6O4P | [MOL File]
182798-83-0.mol | [Molecular Weight]
328.26 |
| Chemical Properties | Back Directory | [Boiling point ]
741.1±70.0 °C(Predicted) | [density ]
1.93±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
2.37±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin[1][2]. | [References]
[1] Compton ML, et al. 9-(2-Phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9-(2-phosphonylmethoxyethyl)guanine (PMEG). Biochem Pharmacol. 1999;58(4):709-714. DOI:10.1016/s0006-2952(99)00138-0
[2] Wolfgang GH, et al. GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009;53(7):2777-2784. DOI:10.1128/AAC.00103-09 |
|
|