| Identification | Back Directory | [Name]
Aminooxy-PEG3-t-butyl ester | [CAS]
1835759-72-2 | [Synonyms]
Aminooxy-PEG3-C2-Boc
Aminooxy-PEG3-t-butyl ester | [Molecular Formula]
C13H27NO6 | [MDL Number]
MFCD29052179 | [MOL File]
1835759-72-2.mol | [Molecular Weight]
293.36 |
| Hazard Information | Back Directory | [Description]
Aminooxy-PEG3-t-butyl ester is an aminooxy-containing PEG molecule. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group is reactive with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The t-butyl ester can be converted tofree acid under acidic condition. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Aminooxy-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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