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2055024-52-5

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2055024-52-5 Structure

2055024-52-5 Structure
IdentificationBack Directory
[Name]

Aminooxy-PEG8-methane
[CAS]

2055024-52-5
[Synonyms]

m-PEG8-Aminooxy
Aminooxy-PEG8-methane
Aminooxy-PEG8-methane HCl salt
Hydroxylamine, O-3,6,9,12,15,18,21,24-octaoxapentacos-1-yl-
[Molecular Formula]

C17H37NO9
[MDL Number]

MFCD31813564
[MOL File]

2055024-52-5.mol
[Molecular Weight]

399.48
Chemical PropertiesBack Directory
[Boiling point ]

476.8±45.0 °C(Predicted)
[density ]

1.079±0.06 g/cm3(Predicted)
[pka]

4.21±0.70(Predicted)
Hazard InformationBack Directory
[Description]

Aminooxy-PEG8-methane is a water soluble PEG reagent containing an aminooxy group and a methane group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
[Uses]

Aminooxy-PEG8-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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