| Identification | Back Directory | [Name]
Aminooxy-PEG2-methane | [CAS]
54149-49-4 | [Synonyms]
m-PEG2-Amino
Aminooxy-PEG2-methane
O-[2-(2-methoxyethoxy)ethyl]hydroxylamine
Hydroxylamine, O-[2-(2-methoxyethoxy)ethyl]- | [Molecular Formula]
C5H13NO3 | [MDL Number]
MFCD21921001 | [MOL File]
54149-49-4.mol | [Molecular Weight]
135.16 |
| Hazard Information | Back Directory | [Description]
Aminooxy-PEG2-methane is a small molecule PEG linker containing an aminooxy group and a methane group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
m-PEG2-Amino is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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