| Identification | Back Directory | [Name]
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol | [CAS]
184475-71-6 | [Synonyms]
FAAH-IN-2
N-(3-Chloro-4-f
Gefitinib iMpurity C
Gefitinib Intermediate 1
Gefitinib interMediate VII
O-Desmorpholinopropyl Gefitinib
4-(3-Chlor-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol
4-(3-Chloro-4-fluoroanilino)-6-hydroxy-7-methoxyquinazoline
6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)aMino]-7-Methoxy-
4-(3-Chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C15H11ClFN3O2 | [MDL Number]
MFCD09908046 | [MOL File]
184475-71-6.mol | [Molecular Weight]
319.72 |
| Chemical Properties | Back Directory | [Appearance]
Tan Solid | [Melting point ]
>260°C (dec.) | [Boiling point ]
478.8±45.0 °C(Predicted) | [density ]
1.489±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Very Slightly, Heated) | [form ]
Solid | [pka]
8.18±0.40(Predicted) | [color ]
Pale Beige to Beige | [InChI]
InChI=1S/C15H11ClFN3O2/c1-22-14-6-12-9(5-13(14)21)15(19-7-18-12)20-8-2-3-11(17)10(16)4-8/h2-7,21H,1H3,(H,18,19,20) | [InChIKey]
JLVTVCRXFMLUIF-UHFFFAOYSA-N | [SMILES]
N1=C2C(C=C(O)C(OC)=C2)=C(NC2=CC=C(F)C(Cl)=C2)N=C1 |
| Hazard Information | Back Directory | [Chemical Properties]
Tan Solid | [Uses]
A metabolite of Gefitinib | [Description]
O-Desmorpholinopropyl Gefitinib is a metabolite of Gefitinib, a potent inhibitor of tyrosine phosporylation in EGFR. The chemical structure of O-Desmorpholinopropyl Gefitinib consists of a quinazoline-6-ol core with a phenylamino group attached to a chloro-fluoro-phenyl ring, enabling it to interact with multiple biological targets. It is involved in inhibiting enzymes such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).
| [Definition]
ChEBI: O-Desmorpholinopropyl Gefitinib is a member of quinazolines. | [storage]
Store at -20°C |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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