| Identification | More | [Name]
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one | [CAS]
199327-61-2 | [Synonyms]
7-METHOXY-6-(3-MORPHOLINOPROPOXY)QUINAZOLIN-4(3H)-ONE
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
7-Methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(3H)-quinazolinone | [EINECS(EC#)]
429-400-7 | [Molecular Formula]
C16H21N3O4 | [MDL Number]
MFCD12760130 | [Molecular Weight]
319.36 | [MOL File]
199327-61-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
233-236 °C | [Boiling point ]
519.5±60.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
7.10±0.10(Predicted) | [color ]
White to Off-White | [Usage]
Gefitinib intermediate | [Major Application]
pharmaceutical | [InChI]
InChI=1S/C16H21N3O4/c1-21-14-10-13-12(16(20)18-11-17-13)9-15(14)23-6-2-3-19-4-7-22-8-5-19/h9-11H,2-8H2,1H3,(H,17,18,20) | [InChIKey]
WFUBWLXSYCFZEH-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)C(=O)NC=1 | [CAS DataBase Reference]
199327-61-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [WGK Germany ]
WGK 2 | [REACH Registrations]
Inactive | [HS Code ]
2933599590 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Chronic 3 |
| Hazard Information | Back Directory | [Description]
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one is a pharmaceutical intermediate used in the preparation of gefitinib, an orally active selective inhibitor of the epidermal growth factor receptor tyrosine kinase, an enzyme that regulates intracellular signalling pathways that associated with the proliferation and survival of cancer cells. | [Chemical Properties]
White Solid | [Uses]
Gefitinib intermediate | [Uses]
Gefitinib intermediate. | [Synthesis]
The preparation method comprises the following steps: with isovanillin as a raw material, carrying out cyanation and nitration so as to obtain 5-hydroxy-4-methoxy-2-nitrobenzonitrile; then carrying out one-pot reduction and cyclization so as to obtain 6-hydroxy-7-methoxy-(3H)-quinazoline-4-one; and finally, carrying out butt joint with a side chain so as to obtain 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one. |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Adamas Reagent, Ltd.
|
| Telephone: |
4006009262 13023226327 |
| Website: |
http://www.tansoole.com |
|