| Identification | Back Directory | [Name]
N-{(1S,2R)-1-benzyl-3-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-hydroxy-3-oxopropyl}-5-chloro-1H-indole-2-carboxaMide|ingliforib | [CAS]
186392-65-4 | [Synonyms]
296
CP296
CP-296
CP 296
CPD2802
GPi 296
CP368296
CP-368296
CP 368296
Ingliforib
Ingliforib (CP 368296
INGLIFORIB; CP-296; CP-368; CP-368;296; CP296; CP 296; CP-368296; CP368296; CP 368296
5-chloro-N-((2S,3R)-4-((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-1H-indole-2-carboxamide
1H-Indole-2-carboxamide, 5-chloro-N-[(1S,2R)-3-[(3R,4S)-3,4-dihydroxy-1-pyrrolidinyl]-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-
N-{(1S,2R)-1-benzyl-3-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-hydroxy-3-oxopropyl}-5-chloro-1H-indole-2-carboxaMide|ingliforib | [Molecular Formula]
C23H24ClN3O5 | [MDL Number]
MFCD30532561 | [MOL File]
186392-65-4.mol | [Molecular Weight]
457.91 |
| Chemical Properties | Back Directory | [Melting point ]
238 °C | [Boiling point ]
843.3±65.0 °C(Predicted) | [density ]
1.495±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:130.0(Max Conc. mg/mL);283.9(Max Conc. mM) | [form ]
Solid | [pka]
12.88±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Treatment of type 2 diabetes mellitus
(glycogen phosphorylase inhibitor). | [Definition]
ChEBI: Ingliforib is an indolecarboxamide. | [in vivo]
Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits[1]. |
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